Tap1 - transporter 1, ATP binding cassette subfamily B member Gene

Rattus norvegicus

Also known as Cim; Tap2; Abcb2

Gene ID: 24811 | Gene type: protein coding

About Tap1

Summary

Enables several functions, including ATP hydrolysis activity; TAP binding activity; and adenyl ribonucleotide binding activity. Contributes to peptide antigen binding activity. Involved in peptide transport and protection from natural killer cell mediated cytotoxicity. Located in intracellular membrane-bounded organelle. Part of TAP complex. Human ortholog(s) of this gene implicated in several diseases, including MHC class I deficiency; autoimmune disease (multiple); bronchial disease (multiple); diffuse scleroderma; and lung disease (multiple). Orthologous to human TAP1 (transporter 1, ATP binding cassette subfamily B member). [provided by Alliance of Genome Resources, Apr 2022]

Tap1 Products(1)

mRNA	Protein	Name
NM_032055.4	NP_114444.2	antigen peptide transporter 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ADP binding	IDA IDA: Inferred from direct assay	15611256	RGD
enables ATP binding	IDA IDA: Inferred from direct assay	12047747	RGD
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	17018292	RGD
enables MHC class I protein binding	IDA IDA: Inferred from direct assay	12047747	RGD
enables TAP1 binding	IPI IPI: Inferred from physical interaction	12047747	RGD
enables TAP2 binding	IPI IPI: Inferred from physical interaction	12047747	RGD
enables nucleotide binding	IDA IDA: Inferred from direct assay	14622282	RGD
contributes to peptide antigen binding	IDA IDA: Inferred from direct assay	10508608	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	18802093	RGD
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	12047747	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	11595746	RGD
enables tapasin binding	IDA IDA: Inferred from direct assay	12047747	RGD
enables tapasin binding	IPI IPI: Inferred from physical interaction	12047747	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in peptide transport	IMP IMP: Inferred from mutant phenotype	15611256	RGD
involved in protection from natural killer cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	8120379	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of MHC class I peptide loading complex	IDA IDA: Inferred from direct assay	17947644	RGD
part of TAP complex	IDA IDA: Inferred from direct assay	11595746	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

antigen peptide transporter 1

APT1	ATP-binding cassette sub-family B member 2
peptide transporter TAP1	transporter 1 ABC (ATP binding cassette)
transporter 1 ATP-binding cassette sub-family B	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P5865	Tap1a	Inhibitor	/	Unkown
HY-RS12607	SEC14L2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14201	TAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17593	Tap1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24053	Tap1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tap1	NCBI	NCBI:6890

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