Slc4a1 - solute carrier family 4 member 1 (Diego blood group) Gene

Rattus norvegicus

Gene ID: 24779 | Gene type: protein coding

About Slc4a1

Summary

Enables actin binding activity; enzyme binding activity; and protein C-terminus binding activity. Involved in several processes, including positive regulation of T cell proliferation; response to alkaline pH; and response to carbon dioxide. Located in several cellular components, including Z disc; basolateral plasma membrane; and intercalated disc. Biomarker of iron deficiency anemia; metabolic acidosis; and renal tubular acidosis. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; hereditary spherocytosis; hereditary spherocytosis type 4; malaria; and renal tubular acidosis. Orthologous to human SLC4A1 (solute carrier family 4 member 1 (Diego blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Slc4a1 Products(1)

mRNA	Protein	Name
NM_012651.2	NP_036783.2	band 3 anion transport protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IPI IPI: Inferred from physical interaction	12898519	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	17652430	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	20946910	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	21903759	RGD
involved in positive regulation of T cell proliferation	IDA IDA: Inferred from direct assay	12165075	RGD
involved in response to acidic pH	IEP IEP: Inferred from expression pattern	10600930	RGD
involved in response to activity	IDA IDA: Inferred from direct assay	24289085	RGD
involved in response to alkaline pH	IEP IEP: Inferred from expression pattern	10600930	RGD
involved in response to arsenic-containing substance	IDA IDA: Inferred from direct assay	20946910	RGD
involved in response to carbon dioxide	IDA IDA: Inferred from direct assay	15075205	RGD
involved in response to hydrogen peroxide	IDA IDA: Inferred from direct assay	20946910	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	21903759	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Z disc	IDA IDA: Inferred from direct assay	12898519	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	9596071	RGD
located in cell surface	IDA IDA: Inferred from direct assay	20114059	RGD
located in intercalated disc	IDA IDA: Inferred from direct assay	12898519	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

band 3 anion transport protein

AE 1	Solute carrier family 4, member 1, anion exchange protein 1 (kidney band 3)
anion exchange protein 1	anion exchanger 1
solute carrier family 4 (anion exchanger), member 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13265	SLC4A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20193	Slc4a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26698	Slc4a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc4a1	NCBI	NCBI:6521

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