Ppp1cc - protein phosphatase 1 catalytic subunit gamma Gene

Rattus norvegicus

Also known as PP-1G; Ppp1cc1

Gene ID: 24669 | Gene type: protein coding

About Ppp1cc

Summary

Enables several functions, including lamin binding activity; protein C-terminus binding activity; and protein Phosphatase 1 binding activity. Involved in positive regulation of glial cell proliferation. Acts upstream of or within neuron differentiation. Located in cytoplasm and dendritic spine. Is active in glutamatergic synapse; postsynapse; and presynapse. Biomarker of congestive heart failure. Orthologous to human PPP1CC (protein Phosphatase 1 catalytic subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]

Ppp1cc Products(2)

mRNA	Protein	Name
NM_001270983.1	NP_001257912.1	serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 2
NM_022498.2	NP_071943.1	serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables lamin binding	IPI IPI: Inferred from physical interaction	17683050	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10391935	RGD
enables protein domain specific binding	IMP IMP: Inferred from mutant phenotype	18216290	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	18216290	RGD
enables protein phosphatase 1 binding	IPI IPI: Inferred from physical interaction	9275233	RGD
enables protein phosphatase binding	IDA IDA: Inferred from direct assay	18216290	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	10504266	RGD

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within neuron differentiation	IDA IDA: Inferred from direct assay	17202132	RGD
involved in positive regulation of glial cell proliferation	IMP IMP: Inferred from mutant phenotype	29033188	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendritic spine	IDA IDA: Inferred from direct assay	7724573	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	7724573	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	7724573	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	7724573	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase PP1-gamma catalytic subunit

protein phosphatase 1, catalytic subunit, gamma isozyme	protein phosphatase 1C catalytic subunit
protein serine-threonine phosphatase catalytic subunit PP-1b

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10975	PPP1CC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19803	Ppp1cc Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26299	Ppp1cc Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppp1cc	NCBI	NCBI:5501

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