Nefh - neurofilament heavy chain Gene

Rattus norvegicus

Also known as Nfh

Gene ID: 24587 | Gene type: protein coding

About Nefh

Summary

Enables protein-macromolecule adaptor activity and toxic substance binding activity. A structural constituent of Cytoskeleton. Involved in several processes, including cellular response to estradiol stimulus; nervous system development; and ovarian follicle atresia. Located in several cellular components, including dendrite; intermediate filament; and perikaryon. Used to study congenital hypothyroidism. Biomarker of glaucoma; hypothyroidism; phenylketonuria; sciatic neuropathy; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2CC; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 1; and monoclonal gammopathy of uncertain significance. Orthologous to human NEFH (neurofilament heavy chain). [provided by Alliance of Genome Resources, Apr 2022]

Nefh Products(1)

mRNA	Protein	Name
NM_012607.2	NP_036739.2	neurofilament heavy polypeptide

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	9388258	RGD
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	11034913	RGD
enables structural constituent of cytoskeleton	IDA IDA: Inferred from direct assay	11034913	RGD
enables toxic substance binding	IDA IDA: Inferred from direct assay	9221839	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in axon regeneration	IDA IDA: Inferred from direct assay	10646539	RGD
involved in cellular response to estradiol stimulus	IEP IEP: Inferred from expression pattern	17401155	RGD
involved in cellular response to hydroperoxide	IEP IEP: Inferred from expression pattern	30041238	RGD
involved in cellular response to oxidative stress	IEP IEP: Inferred from expression pattern	17401155	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	10439464	RGD
involved in hippocampus development	IEP IEP: Inferred from expression pattern	14620872	RGD
involved in intermediate filament bundle assembly	IGI IGI: Inferred from genetic interaction	11034913	RGD
involved in neuron projection development	IEP IEP: Inferred from expression pattern	1898595	RGD
involved in ovarian follicle atresia	IDA IDA: Inferred from direct assay	22315443	RGD
involved in response to acrylamide	IEP IEP: Inferred from expression pattern	17043767	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	24507117	RGD
involved in response to sodium arsenite	IDA IDA: Inferred from direct assay	18674524	RGD
involved in spinal cord development	IEP IEP: Inferred from expression pattern	2108255	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical dendrite	IDA IDA: Inferred from direct assay	27457532	RGD
located in axon	IDA IDA: Inferred from direct assay	7507064	RGD
located in basal proximal dendrite	IDA IDA: Inferred from direct assay	27457532	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	11034913	RGD
located in intermediate filament	IDA IDA: Inferred from direct assay	2230956	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	27457532	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	8544917	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neurofilament heavy polypeptide

200 kDa neurofilament protein	NF-H
neurofilament triplet H protein	neurofilament, heavy polypeptide

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09183	NEFH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22249	Nefh Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28771	Nefh Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nefh	NCBI	NCBI:4744

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