Nlgn3 - neuroligin 3 Gene

Mus musculus

Also known as NL3; HNL3; NLG3; A230085M13Rik

Gene ID: 245537 | Gene type: protein coding

About Nlgn3

Summary

Predicted to enable several functions, including cell adhesion molecule binding activity; neurexin family protein binding activity; and scaffold protein binding activity. Involved in several processes, including modulation of chemical synaptic transmission; regulation of neurotransmitter receptor activity; and regulation of synapse organization. Acts upstream of or within several processes, including oligodendrocyte differentiation; regulation of respiratory gaseous exchange by nervous system process; and visual learning. Predicted to be located in endocytic vesicle; excitatory synapse; and neuronal cell body. Predicted to be integral component of postsynaptic membrane. Predicted to be active in cell surface and synapse. Predicted to be integral component of postsynaptic specialization membrane. Predicted to colocalize with dendrite and inhibitory synapse. Is expressed in several structures, including central nervous system; eye; and heart. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in Asperger syndrome and autistic disorder. Orthologous to human NLGN3 (neuroligin 3). [provided by Alliance of Genome Resources, Apr 2022]

Nlgn3 Products(1)

mRNA	Protein	Name
NM_172932.4	NP_766520.2	neuroligin-3 precursor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	21808020	MGI
acts upstream of or within inhibitory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	17823315	MGI
involved in inhibitory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	21808020	MGI
involved in long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	21808020	MGI
acts upstream of or within modulation of chemical synaptic transmission	IGI IGI: Inferred from genetic interaction	16982420	MGI
involved in negative regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	21808020	MGI
involved in negative regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	21808020	MGI
acts upstream of or within oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	19139271	MGI
involved in positive regulation of AMPA receptor activity	IMP IMP: Inferred from mutant phenotype	21642956	MGI
involved in positive regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	21642956	MGI
involved in positive regulation of glutamate receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21642956	MGI
involved in positive regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	21642956	MGI
involved in positive regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	21642956	MGI
involved in positive regulation of synaptic vesicle clustering	IMP IMP: Inferred from mutant phenotype	21808020	MGI
involved in postsynaptic membrane assembly	IMP IMP: Inferred from mutant phenotype	21642956	MGI
involved in regulation of AMPA receptor activity	IMP IMP: Inferred from mutant phenotype	21808020	MGI
involved in regulation of NMDA receptor activity	IMP IMP: Inferred from mutant phenotype	21808020	MGI
involved in regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	21808020	MGI
involved in regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	21808020	MGI
acts upstream of or within regulation of respiratory gaseous exchange by nervous system process	IGI IGI: Inferred from genetic interaction	16982420	MGI
involved in regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	21808020	MGI
involved in regulation of terminal button organization	IMP IMP: Inferred from mutant phenotype	21808020	MGI
acts upstream of or within social behavior	IMP IMP: Inferred from mutant phenotype	17823315	MGI
involved in social behavior	IMP IMP: Inferred from mutant phenotype	21808020	MGI
acts upstream of or within synapse organization	IGI IGI: Inferred from genetic interaction	21788371	MGI
acts upstream of or within visual learning	IMP IMP: Inferred from mutant phenotype	17823315	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neuroligin-3

gliotactin homolog

neuroligin 3 protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09341	NLGN3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18397	Nlgn3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24879	Nlgn3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nlgn3	NCBI	NCBI:54413

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