Ldhb - lactate dehydrogenase B Gene

Rattus norvegicus

Also known as Ldh2

Gene ID: 24534 | Gene type: protein coding

About Ldhb

Summary

This gene encodes the B subunit of Lactate Dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have also been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 9. [provided by RefSeq, Feb 2016]

Ldhb Products(3)

mRNA	Protein	Name
NM_001316333.1	NP_001303262.1	L-lactate dehydrogenase B chain isoform Ldhbx
NM_001316334.1	NP_001303263.1	L-lactate dehydrogenase B chain isoform Ldhb
NM_012595.2	NP_036727.1	L-lactate dehydrogenase B chain isoform Ldhb

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-lactate dehydrogenase activity	IDA IDA: Inferred from direct assay	17447164	RGD
enables NAD binding	IDA IDA: Inferred from direct assay	17447164	RGD
enables identical protein binding	IDA IDA: Inferred from direct assay	7138505	RGD
enables kinase binding	IPI IPI: Inferred from physical interaction	17572440	RGD
enables lactate dehydrogenase activity	IDA IDA: Inferred from direct assay	7138505	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	7138505	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in NAD metabolic process	IDA IDA: Inferred from direct assay	17447164	RGD
involved in lactate metabolic process	IDA IDA: Inferred from direct assay	17447164	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

L-lactate dehydrogenase B chain

LDH heart subunit	LDH-B
LDH-H	Lactate dehydrogenease B

Related Agents

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W040118	Galloflavin	Inhibitor	99.36%	Unkown
HY-100742A	(R)-GNE-140	Inhibitor	99.73%	Unkown
HY-147216	AXKO-0046	Inhibitor	99.77%	Unkown
HY-111108	LDH-IN-1	Inhibitor	99.84%	Unkown
HY-124309	NHI-2		99.30%	Unkown
HY-147216A	AXKO-0046 dihydrochloride	Inhibitor	99.68%	Unkown
HY-152261	MS6105		99.2%	Unkown
HY-RS07572	LDHB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-162629	LDHA-IN-7	Inhibitor	/	Unkown
HY-RS16989	Ldhb Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23432	Ldhb Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ldhb	NCBI	NCBI:3945

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