Igfbp3 - insulin-like growth factor binding protein 3 Gene

Rattus norvegicus

Also known as IGF-BP3

Gene ID: 24484 | Gene type: protein coding

About Igfbp3

Summary

Enables insulin-like growth factor II binding activity. Involved in several processes, including cellular response to Thyroglobulin triiodothyronine; cellular response to estradiol stimulus; and response to peptide hormone. Located in extracellular space; heterochromatin; and platelet alpha granule. Part of insulin-like growth factor binary complex and insulin-like growth factor ternary complex. Used to study impotence. Biomarker of congenital diaphragmatic hernia; impotence; and obesity. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Orthologous to human IGFBP3 (Insulin like growth factor binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Igfbp3 Products(1)

mRNA	Protein	Name
NM_012588.2	NP_036720.2	insulin-like growth factor-binding protein 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables insulin-like growth factor II binding	IPI IPI: Inferred from physical interaction	9346943	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9346943	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to Thyroglobulin triiodothyronine	IEP IEP: Inferred from expression pattern	8674839	RGD
involved in cellular response to estradiol stimulus	IEP IEP: Inferred from expression pattern	8674839	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	9449625	RGD
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	22067319	RGD
involved in negative regulation of testosterone secretion	IMP IMP: Inferred from mutant phenotype	25582342	RGD
involved in positive regulation of apoptotic DNA fragmentation	IMP IMP: Inferred from mutant phenotype	15125883	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15935983	RGD
involved in positive regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	15055478	RGD
involved in response to caloric restriction	IEP IEP: Inferred from expression pattern	17635417	RGD
involved in response to growth hormone	IEP IEP: Inferred from expression pattern	19916171	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	22805023	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	8776722	RGD
involved in response to insulin-like growth factor stimulus	IEP IEP: Inferred from expression pattern	8776722	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	15930173	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	7536658	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	20042659	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	15990634	RGD
located in heterochromatin	IDA IDA: Inferred from direct assay	15125883	RGD
part of insulin-like growth factor binary complex	IDA IDA: Inferred from direct assay	9346943	RGD
part of insulin-like growth factor ternary complex	IDA IDA: Inferred from direct assay	9346943	RGD
located in platelet alpha granule	IDA IDA: Inferred from direct assay	9449625	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

insulin-like growth factor-binding protein 3

IBP-3	IGF-binding protein 3
IGFBP-3	insulin-like growth factor-binding protein (IGF-BP3)

Related Agents

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W074890	Palmitoylglycine	Modulator	99.74%	Unkown
HY-N3316	Martynoside	Antagonist	≥99.0%	Unkown
HY-110135A	NBI-31772 hydrate	Inhibitor	99.42%	Unkown
HY-RS06626	IGFBP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-P10403	IGFBP-3 peptide		/	Unkown
HY-RS07792	LRP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14700	TMEM219 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17430	Igfbp3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19096	Tmem219 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23885	Igfbp3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Igfbp3	NCBI	NCBI:3486

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