Hspb1 - heat shock protein family B (small) member 1 Gene

Rattus norvegicus

Also known as Hsp25; Hsp27

Gene ID: 24471 | Gene type: protein coding

About Hspb1

Summary

Enables ubiquitin binding activity. Involved in several processes, including cellular response to butyrate; cellular response to interleukin-11; and response to ischemia. Located in several cellular components, including myofibril; perikaryon; and postsynaptic density membrane. Part of Proteasome complex. Biomarker of Alzheimer's disease and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2F; distal hereditary motor neuropathy type 2B; pancreatic cancer; and sarcoma. Orthologous to human HSPB1 (heat shock protein family B (small) member 1). [provided by Alliance of Genome Resources, Apr 2022]

Hspb1 Products(1)

mRNA	Protein	Name
NM_031970.4	NP_114176.4	heat shock protein beta-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11546764	RGD
enables ubiquitin binding	IDA IDA: Inferred from direct assay	12897149	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to butyrate	IEP IEP: Inferred from expression pattern	11522747	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	16324708	RGD
involved in cellular response to interleukin-11	IEP IEP: Inferred from expression pattern	12730876	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	21900647	RGD
involved in negative regulation of cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	11522747	RGD
involved in negative regulation of regulatory T cell differentiation	IMP IMP: Inferred from mutant phenotype	30287503	RGD
involved in positive regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	18541665	RGD
involved in response to angiotensin	IEP IEP: Inferred from expression pattern	21931298	RGD
involved in response to ischemia	IEP IEP: Inferred from expression pattern	10559386	RGD
involved in response to muscle stretch	IEP IEP: Inferred from expression pattern	21900647	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in I band	IDA IDA: Inferred from direct assay	9396443	RGD
located in M band	IDA IDA: Inferred from direct assay	9396443	RGD
located in axon	IDA IDA: Inferred from direct assay	22617993	RGD
located in cardiac myofibril	IDA IDA: Inferred from direct assay	9396443	RGD
located in dendrite	IDA IDA: Inferred from direct assay	22617993	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	22617993	RGD
located in postsynaptic density membrane	IDA IDA: Inferred from direct assay	22617993	RGD
part of proteasome complex	IDA IDA: Inferred from direct assay	12897149	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

heat shock protein beta-1

HSP 27	heat shock 27 kDa protein 1
heat shock 27kDa protein 1	heat shock protein B1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06438	HSPB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17913	Hspb1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24382	Hspb1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hspb1	NCBI	NCBI:3315

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