Gad1 - glutamate decarboxylase 1 Gene

Rattus norvegicus

Also known as Gad67

Gene ID: 24379 | Gene type: protein coding

About Gad1

Summary

Enables anion binding activity; glutamate decarboxylase activity; and protein N-terminus binding activity. Involved in gamma-aminobutyric acid biosynthetic process and response to xenobiotic stimulus. Located in presynaptic active zone. Used to study diabetes mellitus. Human ortholog(s) of this gene implicated in anxiety disorder; bipolar disorder; developmental and epileptic encephalopathy 89; and schizophrenia. Orthologous to human GAD1 (glutamate decarboxylase 1). [provided by Alliance of Genome Resources, Apr 2022]

Gad1 Products(1)

mRNA	Protein	Name
NM_017007.2	NP_058703.1	glutamate decarboxylase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glutamate binding	IDA IDA: Inferred from direct assay	10812196	RGD
enables glutamate decarboxylase activity	IDA IDA: Inferred from direct assay	1924335	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	7836456	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	7836456	RGD
enables pyridoxal phosphate binding	IDA IDA: Inferred from direct assay	1880546	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	11259512	RGD
involved in cellular response to serotonin	IEP IEP: Inferred from expression pattern	20881131	RGD
involved in gamma-aminobutyric acid biosynthetic process	IDA IDA: Inferred from direct assay	1924335	RGD
involved in positive regulation of locomotion involved in locomotory behavior	IMP IMP: Inferred from mutant phenotype	33293518	RGD
involved in response to auditory stimulus	IEP IEP: Inferred from expression pattern	22428005	RGD
involved in response to caloric restriction	IEP IEP: Inferred from expression pattern	15211593	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	19855903	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	15729141	RGD
involved in response to isolation stress	IEP IEP: Inferred from expression pattern	22356888	RGD
involved in response to methamphetamine hydrochloride	IEP IEP: Inferred from expression pattern	30275762	RGD
involved in response to morphine	IEP IEP: Inferred from expression pattern	15673448	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	19855903	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	23932495	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	19359144	RGD
involved in social behavior	IMP IMP: Inferred from mutant phenotype	33293518	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in neuronal cell body	IDA IDA: Inferred from direct assay	20659561	RGD
located in presynaptic active zone	IDA IDA: Inferred from direct assay	24613359	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glutamate decarboxylase 1

67 kDa glutamic acid decarboxylase	GAD-67
Glutamate decarboxylase 1 (brain)	glutamate decarboxylase 1 variant GAD67NT
glutamic acid decarboxylase 1

Related Agents

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0161A	Duloxetine hydrochloride	Inhibitor	99.97%	Yes
HY-B0161	Duloxetine	Inhibitor	99.92%	Yes
HY-118901	Opipramol	Antagonist	99.91%	Unkown
HY-B0161AR	Duloxetine hydrochloride (Standard)	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-122487	Troriluzole	Modulator	99.71%	Phase 3

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-118901A	Opipramol dihydrochloride	Antagonist	/	Unkown
HY-122487A	Troriluzole hydrochloride	Modulator	/	Unkown
HY-B0161AS	Duloxetine-d3 hydrochloride	Inhibitor	/	Unkown
HY-B0161AS1	Duloxetine-d7 hydrochloride	Inhibitor	/	Unkown
HY-RS05227	GAD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-B0161S	Duloxetine-d7	Inhibitor	/	Unkown
HY-B0161S3	Duloxetine-d5 oxalate	Inhibitor	/	Unkown
HY-RS17368	Gad1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23822	Gad1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gad1	NCBI	NCBI:2571

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