2. Gene
  3. Chrm2 - cholinergic receptor, muscarinic 2, cardiac Gene

Chrm2 - cholinergic receptor, muscarinic 2, cardiac Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as M2; Chrm-2; AChR-M2

Gene ID: 243764 | Gene type: protein coding

About Chrm2

Summary

Enables G protein-coupled acetylcholine receptor activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within G protein-coupled acetylcholine receptor signaling pathway. Is active in cholinergic synapse. Is expressed in several structures, including alimentary system; central nervous system; heart; retina; and trigeminal nerve. Human ortholog(s) of this gene implicated in several diseases, including Chagas disease; bipolar disorder; heroin dependence; major depressive disorder; and schizophrenia. Orthologous to human CHRM2 (cholinergic receptor muscarinic 2). [provided by Alliance of Genome Resources, Apr 2022]

Chrm2 Products(6)

mRNA Protein Name
NM_001411688.1 NP_001398617.1 muscarinic acetylcholine receptor M2
NM_001411690.1 NP_001398619.1 muscarinic acetylcholine receptor M2
NM_001411691.1 NP_001398620.1 muscarinic acetylcholine receptor M2
NM_001411693.1 NP_001398622.1 muscarinic acetylcholine receptor M2
NM_001411695.1 NP_001398624.1 muscarinic acetylcholine receptor M2
NM_203491.4 NP_987076.2 muscarinic acetylcholine receptor M2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables G protein-coupled acetylcholine receptor activity IMP
IMP: Inferred from mutant phenotype
9990086 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within G protein-coupled acetylcholine receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9990086 MGI
involved in presynaptic modulation of chemical synaptic transmission EXP
EXP: Inferred from Experiment
11880500 MGI
involved in presynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
11880500 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in cholinergic synapse EXP
EXP: Inferred from Experiment
11880500 MGI
is active in cholinergic synapse IMP
IMP: Inferred from mutant phenotype
11880500 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

muscarinic acetylcholine receptor M2

AChR M2

muscarinic acetylcholine receptor 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N8728 Aposcopolamine 98.44% Unkown
HY-RS02661 CHRM2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19417 Chrm2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25908 Chrm2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chrm2 NCBI NCBI:1129