Ets1 - ETS proto-oncogene 1, transcription factor Gene

Rattus norvegicus

Also known as Tpl1; Ets-1; Etsoncb

Gene ID: 24356 | Gene type: protein coding

About Ets1

Summary

Enables Histone Acetyltransferase binding activity and sequence-specific DNA binding activity. Involved in several processes, including angiogenesis involved in wound healing; diencephalon development; and estrous cycle. Located in nucleus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ETS1 (ETS proto-oncogene 1, transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Ets1 Products(1)

mRNA	Protein	Name
NM_012555.2	NP_036687.1	protein C-ets-1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone acetyltransferase binding	IPI IPI: Inferred from physical interaction	22357921	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12145332	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8635216	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiogenesis involved in wound healing	IEP IEP: Inferred from expression pattern	9600079	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	16192649	RGD
involved in estrous cycle	IEP IEP: Inferred from expression pattern	18439600	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	18439600	RGD
involved in hypothalamus development	IEP IEP: Inferred from expression pattern	8946059	RGD
involved in pituitary gland development	IEP IEP: Inferred from expression pattern	8946059	RGD
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	12725417	RGD
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	19148472	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15806297	RGD
involved in regulation of extracellular matrix disassembly	IMP IMP: Inferred from mutant phenotype	16738537	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	12725417	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	15579511	RGD
involved in response to interleukin-1	IEP IEP: Inferred from expression pattern	16046515	RGD
involved in response to laminar fluid shear stress	IEP IEP: Inferred from expression pattern	18636553	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	18272346	RGD
involved in response to salt	IEP IEP: Inferred from expression pattern	31932071	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein C-ets-1

Ets avian erythroblastosis virus E2 oncogene homolog 1 (tumor progression locus 1)	p54
v-ets avian erythroblastosis virus E26 oncogene homolog 1	v-ets erythroblastosis virus E26 oncogene homolog 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04562	ETS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16879	Ets1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23321	Ets1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS28129	Kcnh8 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ets1	NCBI	NCBI:2113

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