2. Gene
  3. Afp - alpha-fetoprotein Gene

Afp - alpha-fetoprotein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 24177 | Gene type: protein coding

About Afp

Summary

Predicted to enable fatty acid binding activity and zinc ion binding activity. Involved in several processes, including cellular response to retinoic acid; liver regeneration; and response to dexamethasone. Located in cytosol and extracellular space. Biomarker of hepatitis. Human ortholog(s) of this gene implicated in hepatitis C. Orthologous to human AFP (alpha fetoprotein). [provided by Alliance of Genome Resources, Apr 2022]

Afp Products(1)

mRNA Protein Name
NM_012493.2 NP_036625.2 alpha-fetoprotein precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
17828713 RGD
involved in cellular response to retinoic acid IEP
IEP: Inferred from expression pattern
7539613 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
16822301 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
2460696 RGD
involved in pancreas development IEP
IEP: Inferred from expression pattern
17880577 RGD
involved in response to dexamethasone IEP
IEP: Inferred from expression pattern
2409527 RGD
involved in response to tetrachloromethane IEP
IEP: Inferred from expression pattern
1711115 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
1711115 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-fetoprotein

alpha-1-fetoprotein

alpha-fetoglobulin

chloride intracellular channel 6

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0600 Tafluprost Control 99.69% Yes
HY-B0601 Tafluprost acid 99.80% Unkown
HY-116733 Tafluprost ethyl ester Agonist / Unkown
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-16031 AFP464 free base Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-103469 Peroxy Orange 1 99.20% Unkown
HY-16031B AFP464 dihydrochloride Inhibitor 99.67% Unkown
HY-105315 AFP-07 Agonist / Unkown
HY-129293 AFP-07 free acid Agonist / Unkown
HY-160042 AFP aptamer sodium / Unkown
HY-RS00435 AFP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15031 TRIM26 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16874 Afp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23316 Afp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Afp NCBI NCBI:174
Canis familiaris Afp NCBI NCBI:403551
Macaca fascicularis Afp NCBI NCBI:102130105
Mus musculus Afp NCBI NCBI:11576