2. Gene
  3. Add2 - adducin 2 Gene

Add2 - adducin 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as beta-ADD

Gene ID: 24171 | Gene type: protein coding

About Add2

Summary

Predicted to enable cytoskeletal protein binding activity; protein dimerization activity; and protein kinase binding activity. Predicted to be a structural constituent of Cytoskeleton. Involved in ion transport. Is active in glutamatergic synapse and postsynapse. Used to study hypertension. Human ortholog(s) of this gene implicated in IgA glomerulonephritis and hypertension. Orthologous to human ADD2 (adducin 2). [provided by Alliance of Genome Resources, Apr 2022]

Add2 Products(2)

mRNA Protein Name
NM_001109880.1 NP_001103350.1 beta-adducin isoform a
NM_012491.2 NP_036623.1 beta-adducin isoform b
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in monoatomic ion transport IMP
IMP: Inferred from mutant phenotype
2059221 RGD
Cellular Component GO Annotation Evidence Reference Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
9679146 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
9679146 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta-adducin

adducin 2 (beta)

adducin beta

adducin-63

erythrocyte adducin subunit beta

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00339 ADD2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18905 Add2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25396 Add2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Add2 NCBI NCBI:119