2. Gene
  3. A4galt - alpha 1,4-galactosyltransferase Gene

A4galt - alpha 1,4-galactosyltransferase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 239559 | Gene type: protein coding

About A4galt

Summary

The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found in the Golgi, is also required for the synthesis of the Bacterial verotoxins receptor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]

A4galt Products(3)

mRNA Protein Name
NM_001004150.4 NP_001004150.2 lactosylceramide 4-alpha-galactosyltransferase
NM_001170954.2 NP_001164425.2 lactosylceramide 4-alpha-galactosyltransferase
NM_001370647.1 NP_001357576.1 lactosylceramide 4-alpha-galactosyltransferase
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables lactosylceramide 4-alpha-galactosyltransferase activity IDA
IDA: Inferred from direct assay
16476743 MGI
enables lactosylceramide 4-alpha-galactosyltransferase activity IMP
IMP: Inferred from mutant phenotype
16476743 MGI
enables toxic substance binding IMP
IMP: Inferred from mutant phenotype
16476743 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within globoside biosynthetic process IDA
IDA: Inferred from direct assay
16476743 MGI
acts upstream of or within globoside biosynthetic process IMP
IMP: Inferred from mutant phenotype
16476743 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lactosylceramide 4-alpha-galactosyltransferase

Gb3 synthase

Gb3/CD77 synthase

UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase

alpha-1,4-N-acetylglucosaminyltransferase

alpha4Gal-T1

globotriaosylceramide synthase

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-E70047 alpha-1,4-Galactosyltransferase (LgtC) / Unkown
HY-149125 Globotriaosylceramide (porcine RBC) Inhibitor / Unkown
HY-RS00013 A4GALT Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18003 A4galt Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24475 A4galt Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens A4galt NCBI NCBI:53947