Gdf7 - growth differentiation factor 7 Gene

Mus musculus

Also known as BMP12

Gene ID: 238057 | Gene type: protein coding

About Gdf7

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. Mice lacking a functional copy of this gene exhibit absence of some spinal dopaminergic neurons and brain defects, male sterility, and premature death. [provided by RefSeq, Sep 2016]

Gdf7 Products(2)

mRNA	Protein	Name
NM_001312876.1	NP_001299805.1	growth/differentiation factor 7 isoform 1 preproprotein
NM_013527.1	NP_038555.1	growth/differentiation factor 7 isoform 2 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16049014	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12741987	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within BMP signaling pathway	IDA IDA: Inferred from direct assay	16049014	MGI
acts upstream of or within BMP signaling pathway	IGI IGI: Inferred from genetic interaction	16049014	MGI
acts upstream of or within axon guidance	IDA IDA: Inferred from direct assay	12639970	MGI
acts upstream of or within branching morphogenesis of an epithelial tube	IMP IMP: Inferred from mutant phenotype	11356025	MGI
acts upstream of or within cell fate commitment	IDA IDA: Inferred from direct assay	15883363	MGI
acts upstream of or within epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	11356025	MGI
acts upstream of or within forebrain morphogenesis	IMP IMP: Inferred from mutant phenotype	10693795	MGI
acts upstream of or within gland morphogenesis	IMP IMP: Inferred from mutant phenotype	11356025	MGI
acts upstream of or within midbrain development	IMP IMP: Inferred from mutant phenotype	10693795	MGI
acts upstream of or within morphogenesis of an epithelial fold	IMP IMP: Inferred from mutant phenotype	11356025	MGI
acts upstream of or within neural tube development	IMP IMP: Inferred from mutant phenotype	10693795	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	21412429	MGI
acts upstream of or within positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	9786991	MGI
involved in positive regulation of tendon cell differentiation	IDA IDA: Inferred from direct assay	21412429	MGI
acts upstream of or within reproductive structure development	IMP IMP: Inferred from mutant phenotype	11356021	MGI
acts upstream of or within roof plate formation	IMP IMP: Inferred from mutant phenotype	10693795	MGI
acts upstream of or within spinal cord association neuron differentiation	IMP IMP: Inferred from mutant phenotype	10693795	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	12741987	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

growth/differentiation factor 7

GDF-7

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05357	GDF7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19900	Gdf7 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26401	Gdf7 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gdf7	NCBI	NCBI:151449

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