RASD2 - RASD family member 2 Gene

Homo sapiens

Also known as Rhes; TEM2

Gene ID: 23551 | Gene type: protein coding

About RASD2

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:35,532,806-35,553,999 (from NCBI)

This gene has 1 transcript (splice variant), 126 orthologues and 35 paralogues. Broad expression in prostate (RPKM 3.2), brain (RPKM 2.7) and 18 other tissues.

Summary

This gene belongs to the Ras superfamily of small GTPases and is enriched in the striatum. The encoded protein functions as an E3 Ligase for attachment of small ubiquitin-like modifier (SUMO). This protein also binds to mutant Huntingtin (mHtt), the protein mutated in Huntington disease (HD). Sumoylation of mHTT by this protein may cause degeneration of the striatum. The protein functions as an activator of mechanistic target of rapamycin 1 (mTOR1), which in turn plays a role in myelination, axon growth and regeneration. Reduced levels of mRNA expressed by this gene were found in HD patients. [provided by RefSeq, Jan 2016]

RASD2 Products(4)

mRNA	Protein	Name
NM_001366725.1	NP_001353654.1	GTP-binding protein Rhes precursor
NM_001376515.1	NP_001363444.1	GTP-binding protein Rhes precursor
NM_001376516.1	NP_001363445.1	GTP-binding protein Rhes precursor
NM_014310.4	NP_055125.2	GTP-binding protein Rhes precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables G-protein beta-subunit binding	IPI IPI: Inferred from physical interaction	19255495	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RASD2 Protein Structure

Ras

0
100
200
266 a.a.

Protein Preferred Names

Protein Names

GTP-binding protein Rhes

Ras homolog enriched in striatum

Related Diseases

Diseases

Alias

Huntington Disease

Huntington'S Disease	Huntington Chorea
Huntington'S Chorea	HD
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Prostate Calculus

Calculus Of Prostate	Prostatic Lithiasis
Stone Of Prostate	Prostatic Stone
Prostate Calculi	Prostatolithiasis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11686	RASD2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RASD2	VGNC	VGNC:107922
Mus musculus	RASD2	MGD	MGI:1922391
Canis familiaris	RASD2	VGNC	VGNC:45365
Rattus norvegicus	RASD2	RGD	RGD:628594
Bos taurus	RASD2	VGNC	VGNC:33741

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