Tmem119 - transmembrane protein 119 Gene

Mus musculus

Also known as obif

Gene ID: 231633 | Gene type: protein coding

About Tmem119

Summary

Involved in several processes, including endochondral ossification; negative regulation of bone resorption; and positive regulation of macromolecule metabolic process. Acts upstream of or within osteoblast differentiation. Located in endoplasmic reticulum and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and skeleton. Orthologous to human TMEM119 (transmembrane protein 119). [provided by Alliance of Genome Resources, Apr 2022]

Tmem119 Products(1)

mRNA	Protein	Name
NM_146162.3	NP_666274.1	transmembrane protein 119 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21239498	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in endochondral ossification	IMP IMP: Inferred from mutant phenotype	22416756	MGI
involved in negative regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	22416756	MGI
involved in negative regulation of myotube differentiation	IDA IDA: Inferred from direct assay	22579779	MGI
acts upstream of or within osteoblast differentiation	IDA IDA: Inferred from direct assay	21239498	MGI
acts upstream of or within osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	21239498	MGI
involved in positive regulation of bone development	IMP IMP: Inferred from mutant phenotype	26207632	MGI
involved in positive regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	20025746	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	22579779	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22416756	MGI
involved in positive regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	22579779	MGI
involved in positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	20025746	MGI
involved in positive regulation of osteoblast proliferation	IDA IDA: Inferred from direct assay	20025746	MGI
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	22579779	MGI
involved in spermatid differentiation	IMP IMP: Inferred from mutant phenotype	26207632	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	26207632	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	21239498	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	20025746	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transmembrane protein 119

osteoblast induction factor

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14655	TMEM119 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21263	Tmem119 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tmem119	NCBI	NCBI:338773

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