Cpeb2 - cytoplasmic polyadenylation element binding protein 2 Gene

Mus musculus

Also known as Cpe-bp2; A630055H10Rik

Gene ID: 231207 | Gene type: protein coding

About Cpeb2

Summary

Enables nucleic acid binding activity and ribosome binding activity. Involved in several processes, including cellular response to arsenic-containing substance; cellular response to hypoxia; and negative regulation of cytoplasmic translation. Acts upstream of or within negative regulation of translational elongation. Located in cytoplasm. Part of messenger ribonucleoprotein complex and polysome. Is expressed in central nervous system. Orthologous to human CPEB2 (cytoplasmic polyadenylation element binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Cpeb2 Products(5)

mRNA	Protein	Name
NM_001177379.2	NP_001170850.1	cytoplasmic polyadenylation element-binding protein 2 isoform 2
NM_001368805.1	NP_001355734.1	cytoplasmic polyadenylation element-binding protein 2 isoform 3
NM_001368806.1	NP_001355735.1	cytoplasmic polyadenylation element-binding protein 2 isoform 4
NM_001368807.1	NP_001355736.1	cytoplasmic polyadenylation element-binding protein 2 isoform 5
NM_175937.4	NP_787951.2	cytoplasmic polyadenylation element-binding protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA 3'-UTR AU-rich region binding	IDA IDA: Inferred from direct assay	18752464	MGI
enables mRNA regulatory element binding translation repressor activity	IDA IDA: Inferred from direct assay	18752464	MGI
enables poly-pyrimidine tract binding	IDA IDA: Inferred from direct assay	12672660	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17927953	MGI
enables ribosome binding	IDA IDA: Inferred from direct assay	22157746	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	18752464	MGI
involved in negative regulation of cytoplasmic translation	IDA IDA: Inferred from direct assay	18752464	MGI
acts upstream of or within negative regulation of translational elongation	IGI IGI: Inferred from genetic interaction	22157746	MGI
involved in regulation of translation at synapse, modulating synaptic transmission	IDA IDA: Inferred from direct assay	29141213	MGI
involved in regulation of translation at synapse, modulating synaptic transmission	IMP IMP: Inferred from mutant phenotype	29141213	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12672660	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	29141213	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	29141213	MGI
located in ribosome	IDA IDA: Inferred from direct assay	22157746	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cytoplasmic polyadenylation element-binding protein 2

CPE-binding protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03092	CPEB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22454	Cpeb2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cpeb2	NCBI	NCBI:132864

Name
Email *

	Sorry, but the email address you supplied was invalid.