Crocc - ciliary rootlet coiled-coil, rootletin Gene

Mus musculus

Gene ID: 230872 | Gene type: protein coding

About Crocc

Summary

Enables actin binding activity; Kinesin binding activity; and structural molecule activity. A structural constituent of Cytoskeleton. Acts upstream of or within ciliary basal body organization; establishment of organelle localization; and tissue homeostasis. Located in several cellular components, including cytoskeleton; photoreceptor inner segment; and subapical part of cell. Is expressed in brain; metanephros; and retina layer. Orthologous to human CROCC (ciliary rootlet coiled-coil, rootletin). [provided by Alliance of Genome Resources, Apr 2022]

Crocc Products(2)

mRNA	Protein	Name
NM_001145958.1	NP_001139430.1	rootletin isoform 2
NM_172122.2	NP_742120.2	rootletin isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IDA IDA: Inferred from direct assay	15870283	MGI
enables kinesin binding	IPI IPI: Inferred from physical interaction	16018997	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	23746204	MGI
enables structural constituent of cytoskeleton	IMP IMP: Inferred from mutant phenotype	15870283	MGI
enables structural molecule activity	IDA IDA: Inferred from direct assay	12427867	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular homeostasis	IMP IMP: Inferred from mutant phenotype	15870283	MGI
acts upstream of or within ciliary basal body organization	IMP IMP: Inferred from mutant phenotype	15870283	MGI
acts upstream of or within epithelial structure maintenance	IMP IMP: Inferred from mutant phenotype	15870283	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	15870283	MGI
acts upstream of or within establishment of organelle localization	IMP IMP: Inferred from mutant phenotype	15870283	MGI
acts upstream of or within photoreceptor cell maintenance	IMP IMP: Inferred from mutant phenotype	15870283	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in 9+2 motile cilium	IDA IDA: Inferred from direct assay	29891944	MGI
located in centriole	IDA IDA: Inferred from direct assay	16339073	MGI
located in ciliary rootlet	IDA IDA: Inferred from direct assay	16018997	MGI
located in ciliary rootlet	IMP IMP: Inferred from mutant phenotype	15870283	MGI
located in photoreceptor inner segment	IDA IDA: Inferred from direct assay	23178122	MGI
located in subapical part of cell	IDA IDA: Inferred from direct assay	29891944	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

rootletin

ciliary rootlet coiled-coil protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03193	CROCC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22457	Crocc Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Crocc	NCBI	NCBI:9696

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