Pias3 - protein inhibitor of activated STAT 3 Gene

Mus musculus

Also known as Pias3l

Gene ID: 229615 | Gene type: protein coding

About Pias3

Summary

Enables SUMO transferase activity. Acts upstream of or within several processes, including TNFSF11-mediated signaling pathway; negative regulation of macromolecule metabolic process; and negative regulation of osteoclast differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; eye; genitourinary system; and maxillary process. Orthologous to human PIAS3 (protein inhibitor of activated STAT 3). [provided by Alliance of Genome Resources, Apr 2022]

Pias3 Products(3)

mRNA	Protein	Name
NM_001165949.1	NP_001159421.1	E3 SUMO-protein ligase PIAS3 isoform 3
NM_018812.2	NP_061282.2	E3 SUMO-protein ligase PIAS3 isoform 2
NM_146135.2	NP_666247.1	E3 SUMO-protein ligase PIAS3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SUMO transferase activity	IDA IDA: Inferred from direct assay	15767674	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11060035	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17442941	MGI
acts upstream of or within negative regulation of gene expression	IDA IDA: Inferred from direct assay	17442941	MGI
acts upstream of or within negative regulation of osteoclast differentiation	IDA IDA: Inferred from direct assay	17442941	MGI
acts upstream of or within negative regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	17442941	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17442941	MGI
acts upstream of or within protein sumoylation	IDA IDA: Inferred from direct assay	15767674	MGI
acts upstream of or within regulation of tumor necrosis factor-mediated signaling pathway	IDA IDA: Inferred from direct assay	17442941	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21812053	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	34459572	MGI
located in nucleus	IDA IDA: Inferred from direct assay	14596924	MGI
is active in postsynaptic cytosol	IDA IDA: Inferred from direct assay	34459572	MGI
is active in presynaptic cytosol	IDA IDA: Inferred from direct assay	34459572	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

E3 SUMO-protein ligase PIAS3

E3 SUMO-protein transferase PIAS3

protein inhibitor of activated STAT protein 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10475	PIAS3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21688	Pias3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pias3	NCBI	NCBI:10401

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