Dmrt2 - doublesex and mab-3 related transcription factor 2 Gene

Mus musculus

Also known as Terra

Gene ID: 226049 | Gene type: protein coding

About Dmrt2

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within embryonic skeletal system development; positive regulation of myotome development; and regulation of somitogenesis. Predicted to be active in nucleus. Is expressed in several structures, including embryo mesenchyme; genitourinary system; limb; oral epithelium; and thymus primordium. Orthologous to human DMRT2 (doublesex and mab-3 related transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Dmrt2 Products(1)

mRNA	Protein	Name
NM_145831.3	NP_665830.1	doublesex- and mab-3-related transcription factor 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	17974128	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17605809	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	17605809	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17605809	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within embryonic skeletal system development	IMP IMP: Inferred from mutant phenotype	16387292	MGI
NOT acts upstream of or within left/right pattern formation	IMP IMP: Inferred from mutant phenotype	21203428	MGI
acts upstream of myotome development	IMP IMP: Inferred from mutant phenotype	16387292	MGI
acts upstream of or within positive regulation of myotome development	IMP IMP: Inferred from mutant phenotype	16387292	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17974128	MGI
acts upstream of or within regulation of somitogenesis	IGI IGI: Inferred from genetic interaction	17974128	MGI
acts upstream of or within regulation of somitogenesis	IMP IMP: Inferred from mutant phenotype	17974128	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

doublesex- and mab-3-related transcription factor 2

doublesex-like 2 protein

terra homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03829	DMRT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21557	Dmrt2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dmrt2	NCBI	NCBI:10655

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