Xrcc5 - X-ray repair complementing defective repair in Chinese hamster cells 5 Gene

Mus musculus

Also known as Ku80; Ku86; CTC85; CTCBF

Gene ID: 22596 | Gene type: protein coding

About Xrcc5

Summary

Predicted to enable several functions, including nucleic acid binding activity; protein C-terminus binding activity; and ubiquitin protein Ligase binding activity. Predicted to contribute to 5'-deoxyribose-5-phosphate lyase activity and double-stranded telomeric DNA binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; hematopoietic stem cell differentiation; and positive regulation of neurogenesis. Located in cytoplasm and nucleus. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease and multiple myeloma. Orthologous to human XRCC5 (X-ray repair cross complementing 5). [provided by Alliance of Genome Resources, Apr 2022]

Xrcc5 Products(3)

mRNA	Protein	Name
NM_001357519.1	NP_001344448.1	X-ray repair cross-complementing protein 5 isoform 2
NM_001357520.1	NP_001344449.1	X-ray repair cross-complementing protein 5 isoform 2
NM_009533.2	NP_033559.2	X-ray repair cross-complementing protein 5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23685356	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	20439489	MGI
acts upstream of or within double-strand break repair	IGI IGI: Inferred from genetic interaction	12531011	MGI
acts upstream of or within double-strand break repair	IMP IMP: Inferred from mutant phenotype	12531011	MGI
acts upstream of or within hematopoietic stem cell differentiation	IMP IMP: Inferred from mutant phenotype	17554309	MGI
acts upstream of or within hematopoietic stem cell proliferation	IMP IMP: Inferred from mutant phenotype	17554309	MGI
acts upstream of or within leptotene	IMP IMP: Inferred from mutant phenotype	17010969	MGI
acts upstream of neurogenesis	IMP IMP: Inferred from mutant phenotype	10716994	MGI
acts upstream of or within positive regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	10716994	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12604618	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12604618	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

X-ray repair cross-complementing protein 5

ATP-dependent DNA helicase 2 subunit 2	ATP-dependent DNA helicase II 80 kDa subunit
CTC box-binding factor 85 kDa subunit	DNA repair protein XRCC5
Ku p80	ku autoantigen protein p86 homolog
nuclear factor IV

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15900	XRCC5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22924	Xrcc5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Xrcc5	NCBI	NCBI:7520

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