Wnt3 - wingless-type MMTV integration site family, member 3 Gene

Mus musculus

Also known as Int-4; Wnt-3

Gene ID: 22415 | Gene type: protein coding

About Wnt3

Summary

Enables protein domain specific binding activity. Involved in positive regulation of Wnt signaling pathway. Acts upstream of or within several processes, including axis specification; embryonic morphogenesis; and generation of neurons. Located in extracellular matrix. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; embryo ectoderm; and genitourinary system. Human ortholog(s) of this gene implicated in tetraamelia syndrome 1. Orthologous to human Wnt3 (Wnt family member 3). [provided by Alliance of Genome Resources, Apr 2022]

Wnt3 Products(1)

mRNA	Protein	Name
NM_009521.3	NP_033547.1	proto-oncogene Wnt-3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10866835	MGI
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	19000841	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Spemann organizer formation at the anterior end of the primitive streak	IMP IMP: Inferred from mutant phenotype	10431240	MGI
acts upstream of or within anatomical structure formation involved in morphogenesis	IMP IMP: Inferred from mutant phenotype	10431240	MGI
acts upstream of or within anterior/posterior axis specification	IMP IMP: Inferred from mutant phenotype	18028899	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	10431240	MGI
acts upstream of or within axon guidance	IDA IDA: Inferred from direct assay	18716223	MGI
acts upstream of or within canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	18403408	MGI
acts upstream of or within dorsal/ventral axis specification	IMP IMP: Inferred from mutant phenotype	12569130	MGI
acts upstream of or within embryonic forelimb morphogenesis	IMP IMP: Inferred from mutant phenotype	12569130	MGI
acts upstream of or within embryonic hindlimb morphogenesis	IMP IMP: Inferred from mutant phenotype	12569130	MGI
acts upstream of or within gamete generation	IGI IGI: Inferred from genetic interaction	23469192	MGI
acts upstream of gene expression	IDA IDA: Inferred from direct assay	19690384	MGI
acts upstream of or within head morphogenesis	IGI IGI: Inferred from genetic interaction	18403408	MGI
acts upstream of or within limb development	IMP IMP: Inferred from mutant phenotype	12569130	MGI
acts upstream of or within mesoderm formation	IMP IMP: Inferred from mutant phenotype	10431240	MGI
acts upstream of or within negative regulation of axon extension involved in axon guidance	IDA IDA: Inferred from direct assay	18716223	MGI
involved in positive regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	23324743	MGI
acts upstream of or within positive regulation of collateral sprouting in absence of injury	IDA IDA: Inferred from direct assay	18716223	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	19690384	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular matrix	IDA IDA: Inferred from direct assay	8167409	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

proto-oncogene Wnt-3

proto-oncogene Int-4	proto-oncogene protein Wnt-3
wingless-related MMTV integration site 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-129079A	TFMB-(S)-2-HG	Inhibitor	99.79%	Unkown
HY-N6031	Dendrophenol	Inhibitor	99.93%	Unkown
HY-122832	ABC99	Inhibitor	98.48%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wnt3	NCBI	NCBI:7473

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