Vwf - Von Willebrand factor Gene

Mus musculus

Also known as VWD; F8VWF; C630030D09; 6820430P06Rik; B130011O06Rik

Gene ID: 22371 | Gene type: protein coding

About Vwf

Summary

Predicted to enable several functions, including chaperone binding activity; identical protein binding activity; and Integrin binding activity. Acts upstream of or within several processes, including liver development; placenta development; and platelet activation. Located in external side of plasma membrane. Is expressed in several structures, including cardiovascular system; extraembryonic component; genitourinary system; leptomeninges; and vitelline blood vessel. Used to study von Willebrand's disease and von Willebrand's disease 2. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Bernard-Soulier syndrome; end stage renal disease; essential thrombocythemia; and von Willebrand's disease (multiple). Orthologous to human VWF (von Willebrand factor). [provided by Alliance of Genome Resources, Apr 2022]

Vwf Products(1)

mRNA	Protein	Name
NM_011708.4	NP_035838.3	von Willebrand factor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18281502	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within activation of blood coagulation via clotting cascade	IDA IDA: Inferred from direct assay	30573509	MGI
acts upstream of or within blood coagulation	IMP IMP: Inferred from mutant phenotype	9689113	MGI
acts upstream of or within cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	11071623	MGI
acts upstream of or within hemostasis	IMP IMP: Inferred from mutant phenotype	9689113	MGI
acts upstream of or within inflammatory response	IDA IDA: Inferred from direct assay	30573509	MGI
acts upstream of or within liver development	IMP IMP: Inferred from mutant phenotype	7854452	MGI
acts upstream of or within placenta development	IMP IMP: Inferred from mutant phenotype	7854452	MGI
NOT acts upstream of or within platelet activation	IMP IMP: Inferred from mutant phenotype	17380206	MGI
acts upstream of or within platelet activation	IMP IMP: Inferred from mutant phenotype	10930441	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Weibel-Palade body	IDA IDA: Inferred from direct assay	30573509	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	8562500	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	30573509	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

von Willebrand factor

Von Willebrand factor homolog

Related Agents

Approval

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99227	Caplacizumab	Inhibitor	≥99.0%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-153999	BT200	Inhibitor	98.20%	Phase 2
HY-147079	Egaptivon pegol	Inhibitor	92.75%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153999A	BT200 sodium		98.20%	Unkown
HY-147079A	Egaptivon pegol sodium	Inhibitor	92.75%	Unkown
HY-P5354	FRETS-VWF73		/	Unkown
HY-RS15735	VWF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-153998	BT100 sodium	Inhibitor	/	Unkown
HY-RS17403	Vwf Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23858	Vwf Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990544	Anti-vWF Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vwf	NCBI	NCBI:7450

Name
Email *

	Sorry, but the email address you supplied was invalid.