Nr1h2 - nuclear receptor subfamily 1, group H, member 2 Gene

Mus musculus

Also known as UR; LXR; Unr; LXRB; NER1; OR-1; Unr2; RIP15; LXRBSV; LXRbeta

Gene ID: 22260 | Gene type: protein coding

About Nr1h2

Summary

Enables DNA binding activity; nuclear receptor activity; and retinoid X receptor binding activity. Involved in several processes, including Cholesterol homeostasis; positive regulation of transport; and regulation of transcription by RNA polymerase II. Acts upstream of or within cellular lipid metabolic process and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human NR1H2 (nuclear receptor subfamily 1 group H member 2). [provided by Alliance of Genome Resources, Apr 2022]

Nr1h2 Products(4)

mRNA	Protein	Name
NM_001285517.1	NP_001272446.1	oxysterols receptor LXR-beta isoform a
NM_001285518.1	NP_001272447.1	oxysterols receptor LXR-beta isoform b
NM_001285519.1	NP_001272448.1	oxysterols receptor LXR-beta isoform b
NM_009473.3	NP_033499.1	oxysterols receptor LXR-beta isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	14739254	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14739254	MGI
enables DNA-binding transcription factor activity	IGI IGI: Inferred from genetic interaction	7760852	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	29431742	MGI
enables nuclear receptor activity	IDA IDA: Inferred from direct assay	14739254	MGI
enables nuclear retinoid X receptor binding	IDA IDA: Inferred from direct assay	7760852	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17936707	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular lipid metabolic process	IDA IDA: Inferred from direct assay	14739254	MGI
involved in cholesterol homeostasis	IDA IDA: Inferred from direct assay	17657314	MGI
involved in cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	18055760	MGI
involved in lipid homeostasis	IMP IMP: Inferred from mutant phenotype	18806227	MGI
involved in negative regulation of cold-induced thermogenesis	IGI IGI: Inferred from genetic interaction	21173252	MGI
involved in negative regulation of proteolysis	IMP IMP: Inferred from mutant phenotype	18806227	MGI
involved in negative regulation of response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	24206663	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20388921	MGI
involved in phosphatidylcholine acyl-chain remodeling	IMP IMP: Inferred from mutant phenotype	24206663	MGI
involved in positive regulation of cholesterol efflux	IDA IDA: Inferred from direct assay	16825483	MGI
acts upstream of or within positive regulation of cholesterol efflux	IGI IGI: Inferred from genetic interaction	23931754	MGI
involved in positive regulation of high-density lipoprotein particle assembly	IDA IDA: Inferred from direct assay	16825483	MGI
involved in positive regulation of lipid storage	IMP IMP: Inferred from mutant phenotype	18806227	MGI
acts upstream of positive regulation of miRNA transcription	IDA IDA: Inferred from direct assay	31501273	MGI
involved in positive regulation of pancreatic juice secretion	IMP IMP: Inferred from mutant phenotype	18806227	MGI
involved in positive regulation of secretion of lysosomal enzymes	IMP IMP: Inferred from mutant phenotype	18806227	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16141411	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14739254	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	7760852	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	18806227	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

oxysterols receptor LXR-beta

LXR beta	liver X receptor beta
retinoid X receptor-interacting protein No.15	ubiquitously-expressed nuclear receptor 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09529	NR1H2 Human Pre-designed siRNA Set A		/	Unkown
HY-RS19726	Nr1h2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26222	Nr1h2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nr1h2	NCBI	NCBI:7376

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