2. Gene
  3. Tph2 - tryptophan hydroxylase 2 Gene

Tph2 - tryptophan hydroxylase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ntph

Gene ID: 216343 | Gene type: protein coding

About Tph2

Summary

Enables tryptophan 5-monooxygenase activity. Predicted to be involved in aromatic amino acid family metabolic process. Predicted to act upstream of or within serotonin biosynthetic process from tryptophan. Located in neuron projection. Is expressed in early conceptus; germ cell of ovary; nervous system; retina; and tongue. Used to study endogenous depression. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autistic disorder; major depressive disorder; and panic disorder. Orthologous to human TPH2 (Tryptophan Hydroxylase 2). [provided by Alliance of Genome Resources, Apr 2022]

Tph2 Products(1)

mRNA Protein Name
NM_173391.3 NP_775567.2 tryptophan 5-hydroxylase 2
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables tryptophan 5-monooxygenase activity IDA
IDA: Inferred from direct assay
12511643 MGI
Cellular Component GO Annotation Evidence Reference Source
located in neuron projection IDA
IDA: Inferred from direct assay
19906978 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tryptophan 5-hydroxylase 2

neuronal tryptophan hydroxylase

tryptophan 5-monooxygenase 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W019599 4-Chloro-L-phenylalanine Inhibitor ≥98.0% Unkown
HY-120083 Rodatristat Inhibitor 99.11% Unkown
HY-RS14933 TPH2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17651 Tph2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24111 Tph2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tph2 NCBI NCBI:121278