2. Gene
  3. Syn1 - synapsin I Gene

Syn1 - synapsin I Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Syn-1; Syn1-S

Gene ID: 20964 | Gene type: protein coding

About Syn1

Summary

Enables identical protein binding activity and protein kinase binding activity. Involved in regulation of synaptic vesicle cycle and synaptic vesicle clustering. Acts upstream of or within neurotransmitter secretion. Located in several cellular components, including Schaffer collateral - CA1 synapse; synaptic vesicle membrane; and synaptonemal complex. Is expressed in diaphragm; intercostal muscle; molar; nervous system; and sensory organ. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in X-linked epilepsy with variable learning disabilities and behavior disorders and non-syndromic X-linked intellectual disability 50. Orthologous to human SYN1 (synapsin I). [provided by Alliance of Genome Resources, Apr 2022]

Syn1 Products(2)

mRNA Protein Name
NM_001110780.1 NP_001104250.1 synapsin-1 isoform b
NM_013680.4 NP_038708.3 synapsin-1 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
15071120 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
21307259 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within neurotransmitter secretion IGI
IGI: Inferred from genetic interaction
7777057 MGI
acts upstream of or within neurotransmitter secretion IMP
IMP: Inferred from mutant phenotype
7777057 MGI
involved in regulation of synaptic vesicle cycle IDA
IDA: Inferred from direct assay
8794863 MGI
involved in regulation of synaptic vesicle cycle IMP
IMP: Inferred from mutant phenotype
8794863 MGI
involved in synaptic vesicle cycle IDA
IDA: Inferred from direct assay
7902212 MGI
involved in synaptic vesicle cycle IMP
IMP: Inferred from mutant phenotype
7902212 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
7902212 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
7902212 MGI
is active in axon IDA
IDA: Inferred from direct assay
17634368 MGI
located in axon IDA
IDA: Inferred from direct assay
15255972 MGI
is active in cell body IDA
IDA: Inferred from direct assay
17634368 MGI
is active in dendrite IDA
IDA: Inferred from direct assay
17634368 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
17114649 MGI
located in presynapse IDA
IDA: Inferred from direct assay
27759003 MGI
located in presynaptic active zone IDA
IDA: Inferred from direct assay
16621800 MGI
located in synapse IDA
IDA: Inferred from direct assay
14622577 MGI
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
15071120 MGI
located in synaptonemal complex IDA
IDA: Inferred from direct assay
14736746 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

synapsin-1

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14079 SYN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14317 TCL1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16954 Sdc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22337 Syn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28859 Syn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Syn1 NCBI NCBI:6853