Sox9 - SRY (sex determining region Y)-box 9 Gene

Mus musculus

Also known as mSox9; mKIAA4243; 2010306G03Rik

Gene ID: 20682 | Gene type: protein coding

About Sox9

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; beta-catenin binding activity; and nucleic acid binding activity. Involved in several processes, including intracellular signal transduction; positive regulation of morphogenesis of an epithelium; and regulation of signal transduction. Acts upstream of or within several processes, including animal organ development; negative regulation of cell differentiation; and regulation of epithelial cell proliferation. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study campomelic dysplasia. Human ortholog(s) of this gene implicated in 46,XX sex reversal 2; 46,XY sex reversal 10; and campomelic dysplasia. Orthologous to human SOX9 (SRY-box transcription factor 9). [provided by Alliance of Genome Resources, Apr 2022]

Sox9 Products(1)

mRNA	Protein	Name
NM_011448.4	NP_035578.3	transcription factor SOX-9

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	18403418	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10805756	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	9755172	MGI
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	17084361	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	17525254	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15590666	MGI
enables beta-catenin binding	IDA IDA: Inferred from direct assay	15132997	MGI
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	19725955	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10805756	MGI
enables pre-mRNA intronic binding	IDA IDA: Inferred from direct assay	24191021	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12381733	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15800003	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	9119111	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	21512138	MGI
acts upstream of or within Harderian gland development	IMP IMP: Inferred from mutant phenotype	24924191	MGI
acts upstream of or within Notch signaling pathway	IDA IDA: Inferred from direct assay	25446530	MGI
acts upstream of or within Sertoli cell development	IGI IGI: Inferred from genetic interaction	19124014	MGI
acts upstream of or within Sertoli cell differentiation	IMP IMP: Inferred from mutant phenotype	15056615	MGI
acts upstream of or within anterior head development	IMP IMP: Inferred from mutant phenotype	26234751	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	16085486	MGI
acts upstream of or within astrocyte fate commitment	IGI IGI: Inferred from genetic interaction	19490914	MGI
acts upstream of bone mineralization	IMP IMP: Inferred from mutant phenotype	11371614	MGI
involved in branching involved in ureteric bud morphogenesis	IEP IEP: Inferred from expression pattern	8787755	MGI
acts upstream of or within bronchus cartilage development	IMP IMP: Inferred from mutant phenotype	24218621	MGI
acts upstream of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	19047045	MGI
acts upstream of or within cartilage condensation	IMP IMP: Inferred from mutant phenotype	10319868	MGI
acts upstream of cartilage development	IDA IDA: Inferred from direct assay	19047045	MGI
involved in cartilage development	IDA IDA: Inferred from direct assay	15529345	MGI
acts upstream of or within cartilage development	IMP IMP: Inferred from mutant phenotype	11371614	MGI
involved in cartilage development	IMP IMP: Inferred from mutant phenotype	28263186	MGI
acts upstream of or within cell fate commitment	IGI IGI: Inferred from genetic interaction	15893981	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17267606	MGI
acts upstream of cell proliferation involved in heart morphogenesis	IMP IMP: Inferred from mutant phenotype	17350610	MGI
acts upstream of or within cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	24191021	MGI
involved in cellular response to epidermal growth factor stimulus	IDA IDA: Inferred from direct assay	21512138	MGI
involved in cellular response to heparin	IDA IDA: Inferred from direct assay	21512138	MGI
involved in cellular response to mechanical stimulus	IDA IDA: Inferred from direct assay	21512138	MGI
acts upstream of or within cellular response to retinoic acid	IDA IDA: Inferred from direct assay	19389355	MGI
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	17525254	MGI
involved in central nervous system development	IEP IEP: Inferred from expression pattern	9119111	MGI
acts upstream of or within chondrocyte development	IMP IMP: Inferred from mutant phenotype	18415932	MGI
involved in chondrocyte differentiation	IDA IDA: Inferred from direct assay	32103177	MGI
involved in chondrocyte differentiation	IEP IEP: Inferred from expression pattern	9119111	MGI
acts upstream of chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	11371614	MGI
acts upstream of or within chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	12414734	MGI
involved in chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	15132997	MGI
involved in chondrocyte hypertrophy	IMP IMP: Inferred from mutant phenotype	21367821	MGI
acts upstream of or within cochlea morphogenesis	IMP IMP: Inferred from mutant phenotype	20346939	MGI
acts upstream of or within cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	24191021	MGI
acts upstream of or within endocardial cushion morphogenesis	IMP IMP: Inferred from mutant phenotype	11951052	MGI
acts upstream of or within endochondral bone morphogenesis	IMP IMP: Inferred from mutant phenotype	11371614	MGI
acts upstream of or within endocrine pancreas development	IMP IMP: Inferred from mutant phenotype	18723011	MGI
involved in epidermal growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	21512138	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	17698607	MGI
acts upstream of or within epithelial cell proliferation involved in prostatic bud elongation	IMP IMP: Inferred from mutant phenotype	18325490	MGI
acts upstream of or within epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	15096597	MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis	IGI IGI: Inferred from genetic interaction	24058167	MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis	IMP IMP: Inferred from mutant phenotype	24058167	MGI
acts upstream of extracellular matrix assembly	IMP IMP: Inferred from mutant phenotype	20881014	MGI
acts upstream of or within extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	17350610	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	29659575	MGI
acts upstream of glandular epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	17681175	MGI
acts upstream of or within glial cell fate specification	IMP IMP: Inferred from mutant phenotype	12842915	MGI
involved in growth plate cartilage chondrocyte growth	IMP IMP: Inferred from mutant phenotype	22421045	MGI
acts upstream of or within hair follicle development	IMP IMP: Inferred from mutant phenotype	16085486	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	15096597	MGI
involved in heart valve development	IMP IMP: Inferred from mutant phenotype	20056916	MGI
acts upstream of or within heart valve formation	IMP IMP: Inferred from mutant phenotype	17350610	MGI
acts upstream of or within heart valve morphogenesis	IMP IMP: Inferred from mutant phenotype	17350610	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IMP IMP: Inferred from mutant phenotype	24218621	MGI
acts upstream of intestinal epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	17681175	MGI
acts upstream of or within intestinal epithelial structure maintenance	IMP IMP: Inferred from mutant phenotype	17681175	MGI
acts upstream of or within intrahepatic bile duct development	IMP IMP: Inferred from mutant phenotype	19403103	MGI
acts upstream of or within lacrimal gland development	IMP IMP: Inferred from mutant phenotype	24924191	MGI
involved in limb bud formation	IEP IEP: Inferred from expression pattern	20940257	MGI
acts upstream of or within lung epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	24191021	MGI
acts upstream of or within lung smooth muscle development	IMP IMP: Inferred from mutant phenotype	24218621	MGI
acts upstream of or within male germ-line sex determination	IMP IMP: Inferred from mutant phenotype	11431689	MGI
involved in male gonad development	IEP IEP: Inferred from expression pattern	8787755	MGI
acts upstream of or within male gonad development	IGI IGI: Inferred from genetic interaction	15056615	MGI
acts upstream of or within male gonad development	IMP IMP: Inferred from mutant phenotype	11431689	MGI
acts upstream of or within male sex determination	IGI IGI: Inferred from genetic interaction	16700629	MGI
involved in mammary gland development	IEP IEP: Inferred from expression pattern	12420222	MGI
acts upstream of mesenchymal cell apoptotic process	IMP IMP: Inferred from mutant phenotype	24058167	MGI
acts upstream of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	17350610	MGI
acts upstream of or within metanephric nephron tubule formation	IGI IGI: Inferred from genetic interaction	21212101	MGI
involved in metanephric tubule development	IEP IEP: Inferred from expression pattern	8787755	MGI
acts upstream of or within morphogenesis of a branching epithelium	IGI IGI: Inferred from genetic interaction	21212101	MGI
acts upstream of or within morphogenesis of a branching epithelium	IMP IMP: Inferred from mutant phenotype	24924191	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12782625	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	21212101	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16085486	MGI
involved in negative regulation of beta-catenin-TCF complex assembly	IMP IMP: Inferred from mutant phenotype	15132997	MGI
involved in negative regulation of biomineral tissue development	IMP IMP: Inferred from mutant phenotype	20056916	MGI
acts upstream of or within negative regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	11371614	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	17698607	MGI
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	17875931	MGI
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	15132997	MGI
acts upstream of or within negative regulation of chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	11371614	MGI
acts upstream of or within negative regulation of epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	24058167	MGI
acts upstream of or within negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	17681175	MGI
involved in negative regulation of fatty acid oxidation	IDA IDA: Inferred from direct assay	32103177	MGI
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24218621	MGI
involved in negative regulation of immune system process	IMP IMP: Inferred from mutant phenotype	20056916	MGI
acts upstream of or within negative regulation of mesenchymal cell apoptotic process	IMP IMP: Inferred from mutant phenotype	24058167	MGI
acts upstream of or within negative regulation of myoblast differentiation	IDA IDA: Inferred from direct assay	12782625	MGI
involved in negative regulation of ossification	IMP IMP: Inferred from mutant phenotype	20056916	MGI
involved in negative regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	31121357	MGI
involved in negative regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	22421045	MGI
acts upstream of or within negative regulation of photoreceptor cell differentiation	IGI IGI: Inferred from genetic interaction	19490914	MGI
acts upstream of or within neural crest cell development	IMP IMP: Inferred from mutant phenotype	15691760	MGI
acts upstream of or within neuron fate specification	IMP IMP: Inferred from mutant phenotype	12842915	MGI
involved in notochord development	IEP IEP: Inferred from expression pattern	9119111	MGI
acts upstream of or within oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	17084361	MGI
involved in ossification	IEP IEP: Inferred from expression pattern	9119111	MGI
involved in otic vesicle development	IEP IEP: Inferred from expression pattern	9119111	MGI
acts upstream of or within otic vesicle formation	IMP IMP: Inferred from mutant phenotype	18377888	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15778499	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9119111	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	17084361	MGI
involved in positive regulation of branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	21212101	MGI
acts upstream of or within positive regulation of cartilage development	IDA IDA: Inferred from direct assay	19047045	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17267606	MGI
acts upstream of or within positive regulation of cell proliferation involved in heart morphogenesis	IMP IMP: Inferred from mutant phenotype	17350610	MGI
involved in positive regulation of chondrocyte differentiation	IDA IDA: Inferred from direct assay	20940257	MGI
involved in positive regulation of chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	21367821	MGI
acts upstream of or within positive regulation of epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	17681175	MGI
acts upstream of or within positive regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	24191021	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	20346939	MGI
involved in positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	20103652	MGI
acts upstream of or within positive regulation of extracellular matrix assembly	IMP IMP: Inferred from mutant phenotype	20881014	MGI
acts upstream of or within positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	19124014	MGI
involved in positive regulation of kidney development	IGI IGI: Inferred from genetic interaction	21212101	MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	17350610	MGI
acts upstream of or within positive regulation of protein catabolic process	IDA IDA: Inferred from direct assay	19047045	MGI
acts upstream of or within positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	19047045	MGI
acts upstream of or within positive regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	17350610	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9171829	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17525254	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	9755172	MGI
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	22110751	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21757499	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20940257	MGI
involved in prostate gland development	IEP IEP: Inferred from expression pattern	20103652	MGI
acts upstream of or within prostate gland morphogenesis	IMP IMP: Inferred from mutant phenotype	18325490	MGI
acts upstream of or within protein localization to nucleus	IDA IDA: Inferred from direct assay	21427722	MGI
acts upstream of protein phosphorylation	IDA IDA: Inferred from direct assay	19047045	MGI
acts upstream of or within regulation of branching involved in lung morphogenesis	IMP IMP: Inferred from mutant phenotype	24191021	MGI
acts upstream of or within regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	18377888	MGI
acts upstream of or within regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	17698607	MGI
acts upstream of or within regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16085486	MGI
acts upstream of or within regulation of cell proliferation involved in tissue homeostasis	IMP IMP: Inferred from mutant phenotype	17698607	MGI
acts upstream of or within regulation of epithelial cell proliferation involved in lung morphogenesis	IMP IMP: Inferred from mutant phenotype	24191021	MGI
acts upstream of or within regulation of gene expression	IDA IDA: Inferred from direct assay	27325675	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19796622	MGI
involved in renal vesicle induction	IMP IMP: Inferred from mutant phenotype	21212101	MGI
involved in response to fatty acid	IDA IDA: Inferred from direct assay	32103177	MGI
acts upstream of or within retina development in camera-type eye	IGI IGI: Inferred from genetic interaction	19490914	MGI
acts upstream of retinal rod cell differentiation	IGI IGI: Inferred from genetic interaction	19490914	MGI
acts upstream of or within retinal rod cell differentiation	IGI IGI: Inferred from genetic interaction	19490914	MGI
involved in signal transduction	IMP IMP: Inferred from mutant phenotype	21212101	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	20871603	MGI
acts upstream of or within spermatogenesis	IGI IGI: Inferred from genetic interaction	19124014	MGI
acts upstream of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	17350610	MGI
involved in tissue homeostasis	IMP IMP: Inferred from mutant phenotype	20056916	MGI
acts upstream of or within trachea cartilage development	IMP IMP: Inferred from mutant phenotype	24218621	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17644814	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	21427722	MGI
acts upstream of type I pneumocyte differentiation	IMP IMP: Inferred from mutant phenotype	24058167	MGI
acts upstream of or within ureter development	IGI IGI: Inferred from genetic interaction	20881014	MGI
acts upstream of or within ureter morphogenesis	IGI IGI: Inferred from genetic interaction	21212101	MGI
acts upstream of or within ureter smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	20881014	MGI
involved in ureter urothelium development	IEP IEP: Inferred from expression pattern	21512138	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	10805756	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	22344693	MGI
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	21346191	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor SOX-9

SRY-box containing gene 9

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13599	SOX9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17376	Sox9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23830	Sox9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sox9	NCBI	NCBI:6662

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