Sox6 - SRY (sex determining region Y)-box 6 Gene

Mus musculus

Also known as SOX-LZ

Gene ID: 20679 | Gene type: protein coding

About Sox6

Summary

This gene encodes a member of a family of transcriptional regulators containing high mobility group (HMG) DNA-binding domains. Function of the encoded protein is important for proper cardiac and skeletal development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Sox6 Products(6)

mRNA	Protein	Name
NM_001025559.3	NP_001020730.1	transcription factor SOX-6 isoform 2
NM_001025560.2	NP_001020731.1	transcription factor SOX-6 isoform 3
NM_001277326.1	NP_001264255.1	transcription factor SOX-6 isoform 1
NM_001277327.1	NP_001264256.1	transcription factor SOX-6 isoform 2
NM_001277328.1	NP_001264257.1	transcription factor SOX-6 isoform 4
NM_011445.4	NP_035575.1	transcription factor SOX-6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12446692	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12446692	MGI
enables DNA-binding transcription factor activity	IGI IGI: Inferred from genetic interaction	9755172	MGI
enables DNA-binding transcription repressor activity	IDA IDA: Inferred from direct assay	26525805	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	16462943	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	27880909	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	16462943	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9755172	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16462943	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	17084361	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cardiac muscle cell differentiation	IDA IDA: Inferred from direct assay	14530442	MGI
involved in cartilage condensation	IMP IMP: Inferred from mutant phenotype	11702786	MGI
involved in cartilage development	IDA IDA: Inferred from direct assay	15529345	MGI
acts upstream of or within cartilage development	IGI IGI: Inferred from genetic interaction	15634692	MGI
involved in cartilage development	IMP IMP: Inferred from mutant phenotype	26150426	MGI
acts upstream of or within cell fate commitment	IGI IGI: Inferred from genetic interaction	15634692	MGI
acts upstream of or within cell morphogenesis	IMP IMP: Inferred from mutant phenotype	16462943	MGI
involved in chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	11702786	MGI
acts upstream of or within erythrocyte development	IMP IMP: Inferred from mutant phenotype	16462943	MGI
acts upstream of or within erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	20711497	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	27880909	MGI
acts upstream of or within hemopoiesis	IMP IMP: Inferred from mutant phenotype	16462943	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	17084361	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17084361	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	16462943	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16462943	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16462943	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16462943	MGI
acts upstream of or within oligodendrocyte cell fate specification	IMP IMP: Inferred from mutant phenotype	17084361	MGI
acts upstream of or within oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	17084361	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	17084361	MGI
involved in positive regulation of chondrocyte differentiation	IDA IDA: Inferred from direct assay	20940257	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	9755172	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	16462943	MGI
involved in regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	27880909	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12446692	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20711497	MGI
involved in spinal cord oligodendrocyte cell differentiation	IMP IMP: Inferred from mutant phenotype	26525805	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	9755172	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor SOX-6

SRY-box containing gene 6

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13597	SOX6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20338	Sox6 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26846	Sox6 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sox6	NCBI	NCBI:55553

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