Slc1a3 - solute carrier family 1 (glial high affinity glutamate transporter), member 3 Gene

Mus musculus

Also known as Gmt1; Eaat1; GLAST; GLU-T; GluT-1; MGluT1; GLAST-1; B430115D02Rik

Gene ID: 20512 | Gene type: protein coding

About Slc1a3

Summary

Enables glutamate binding activity and high-affinity glutamate transmembrane transporter activity. Involved in D-aspartate import across plasma membrane and cellular response to cocaine. Acts upstream of or within several processes, including L-glutamate import across plasma membrane; gamma-aminobutyric acid biosynthetic process; and nervous system development. Located in several cellular components, including cell surface; neuron projection; and neuronal cell body. Is integral component of plasma membrane. Is expressed in several structures, including brain; connective tissue; eye; genitourinary system; and spinal cord. Used to study low tension glaucoma. Human ortholog(s) of this gene implicated in episodic ataxia type 6. Orthologous to human SLC1A3 (solute carrier family 1 member 3). [provided by Alliance of Genome Resources, Apr 2022]

Slc1a3 Products(1)

mRNA	Protein	Name
NM_148938.3	NP_683740.1	excitatory amino acid transporter 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables acidic amino acid transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	28032905	MGI
enables amino acid binding	IDA IDA: Inferred from direct assay	7903437	MGI
enables glutamate binding	IDA IDA: Inferred from direct assay	7903437	MGI
enables high-affinity L-glutamate transmembrane transporter activity	IDA IDA: Inferred from direct assay	7903437	MGI
enables high-affinity L-glutamate transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	15390100	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14723703	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in D-aspartate import across plasma membrane	IMP IMP: Inferred from mutant phenotype	28032905	MGI
acts upstream of or within L-glutamate import	IMP IMP: Inferred from mutant phenotype	15390100	MGI
acts upstream of or within L-glutamate import across plasma membrane	IMP IMP: Inferred from mutant phenotype	15140926	MGI
acts upstream of or within L-glutamate transmembrane transport	IDA IDA: Inferred from direct assay	14723703	MGI
acts upstream of or within auditory behavior	IMP IMP: Inferred from mutant phenotype	11102482	MGI
acts upstream of or within cell morphogenesis involved in neuron differentiation	IMP IMP: Inferred from mutant phenotype	9753165	MGI
involved in cellular response to cocaine	IDA IDA: Inferred from direct assay	27208619	MGI
acts upstream of or within cranial nerve development	IMP IMP: Inferred from mutant phenotype	9753165	MGI
acts upstream of or within gamma-aminobutyric acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	15305132	MGI
acts upstream of or within intracellular sodium ion homeostasis	IMP IMP: Inferred from mutant phenotype	19766171	MGI
acts upstream of or within neuromuscular process controlling balance	IMP IMP: Inferred from mutant phenotype	9753165	MGI
acts upstream of or within positive regulation of synaptic transmission	IMP IMP: Inferred from mutant phenotype	9539795	MGI
acts upstream of or within response to antibiotic	IMP IMP: Inferred from mutant phenotype	15862894	MGI
acts upstream of or within response to light stimulus	IMP IMP: Inferred from mutant phenotype	9539795	MGI
acts upstream of or within response to wounding	IMP IMP: Inferred from mutant phenotype	9753165	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	9539795	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	11102482	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell periphery	IDA IDA: Inferred from direct assay	20531390	MGI
located in cell projection	IDA IDA: Inferred from direct assay	9671661	MGI
located in cell surface	IDA IDA: Inferred from direct assay	14723703	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	20531390	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	9364068	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	14723703	MGI
located in synapse	IDA IDA: Inferred from direct assay	12558972	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

excitatory amino acid transporter 1

glial high affinity glutamate transporter	glutamate/aspartate transporter
high-affinity neuronal glutamate transporter	sodium-dependent glutamate/aspartate transporter 1
solute carrier family 1, member 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13054	SLC1A3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19528	Slc1a3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26023	Slc1a3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc1a3	NCBI	NCBI:6507

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