2. Gene
  3. Six6 - sine oculis-related homeobox 6 Gene

Six6 - sine oculis-related homeobox 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Six9; Optx2

Gene ID: 20476 | Gene type: protein coding

About Six6

Summary

This gene encodes a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 12 and is thought to be involved in eye development. The encoded transcription factor regulates early progenitor cell proliferation during mammalian retinogenesis and pituitary development. Mice lacking this gene exhibit abnormal development of the suprachiasmatic nucleus and circadian rhythms. [provided by RefSeq, Sep 2015]

Six6 Products(2)

mRNA Protein Name
NM_011384.5 NP_035514.1 homeobox protein SIX6
NM_011384.5 NP_035514.1 homeobox protein SIX6
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
18836447 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12050133 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein SIX6

optic homeobox 2

sine oculis homeobox homolog 6

sine oculis-related homeobox 6 homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12963 SIX6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22325 Six6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28847 Six6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Six6 NCBI NCBI:4990