Six5 - sine oculis-related homeobox 5 Gene

Mus musculus

Also known as Dmahp; MDMAHP; TrexBF

Gene ID: 20475 | Gene type: protein coding

About Six5

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of skeletal muscle satellite cell proliferation; negative regulation of transcription, DNA-templated; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within lens development in camera-type eye; negative regulation of cell population proliferation; and spermatid development. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in branchiootorenal syndrome 2. Orthologous to human SIX5 (SIX homeobox 5). [provided by Alliance of Genome Resources, Apr 2022]

Six5 Products(1)

mRNA	Protein	Name
NM_011383.1	NP_035513.1	homeobox protein SIX5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	14966291	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	20696153	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8814301	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8814301	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of Leydig cell proliferation	IMP IMP: Inferred from mutant phenotype	15163633	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15163633	MGI
acts upstream of or within lens development in camera-type eye	IMP IMP: Inferred from mutant phenotype	10802667	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20696153	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15163633	MGI
involved in negative regulation of skeletal muscle satellite cell proliferation	IMP IMP: Inferred from mutant phenotype	20696153	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20696153	MGI
acts upstream of or within spermatid development	IMP IMP: Inferred from mutant phenotype	15163633	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	8814301	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox protein SIX5

DM locus-associated homeodomain protein homolog	sine oculis homeobox homolog 5
sine oculis-related homeobox 5 homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12962	SIX5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21435	Six5 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Six5	NCBI	NCBI:147912

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