2. Gene
  3. Rasgrp1 - RAS guanyl releasing protein 1 Gene

Rasgrp1 - RAS guanyl releasing protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Rasgrp; calDAG-GEFII

Gene ID: 19419 | Gene type: protein coding

About Rasgrp1

Summary

Predicted to enable several functions, including cation binding activity; diacylglycerol binding activity; and guanyl-nucleotide exchange factor activity. Involved in positive regulation of T cell differentiation in thymus and positive regulation of natural killer cell differentiation. Acts upstream of or within several processes, including activation of GTPase activity; mast cell degranulation; and regulation of phosphatidylinositol 3-kinase signaling. Predicted to be located in Golgi apparatus; cytosol; and plasma membrane. Is expressed in brain; olfactory epithelium; olfactory lobe; and telencephalon mantle layer. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in immunodeficiency 64. Orthologous to human RASGRP1 (Ras guanyl releasing protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Rasgrp1 Products(1)

mRNA Protein Name
NM_011246.3 NP_035376.1 RAS guanyl-releasing protein 1
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within activation of GTPase activity IMP
IMP: Inferred from mutant phenotype
17190838 MGI
involved in activation of GTPase activity IMP
IMP: Inferred from mutant phenotype
11017103 MGI
acts upstream of or within inflammatory response to antigenic stimulus IMP
IMP: Inferred from mutant phenotype
17190838 MGI
acts upstream of or within mast cell cytokine production IMP
IMP: Inferred from mutant phenotype
17190838 MGI
acts upstream of or within mast cell degranulation IMP
IMP: Inferred from mutant phenotype
17190838 MGI
involved in positive regulation of T cell differentiation in thymus IMP
IMP: Inferred from mutant phenotype
11017103 MGI
involved in positive regulation of natural killer cell activation IMP
IMP: Inferred from mutant phenotype
21957144 MGI
involved in positive regulation of natural killer cell differentiation IMP
IMP: Inferred from mutant phenotype
21957144 MGI
acts upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
17190838 MGI
acts upstream of or within secretory granule localization IMP
IMP: Inferred from mutant phenotype
17190838 MGI
acts upstream of or within vesicle transport along microtubule IMP
IMP: Inferred from mutant phenotype
17190838 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

RAS guanyl-releasing protein 1

calcium and DAG-regulated guanine nucleotide exchange factor II

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11693 RASGRP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS22023 Rasgrp1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rasgrp1 NCBI NCBI:10125