Aldh1a2 - aldehyde dehydrogenase family 1, subfamily A2 Gene

Mus musculus

Also known as Raldh1; Raldh2; Aldh1a7

Gene ID: 19378 | Gene type: protein coding

About Aldh1a2

Summary

Enables 3-chloroallyl aldehyde dehydrogenase activity and retinal dehydrogenase activity. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and retinoid metabolic process. Predicted to be located in cytosol and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study DiGeorge syndrome. Orthologous to human ALDH1A2 (aldehyde dehydrogenase 1 family member A2). [provided by Alliance of Genome Resources, Apr 2022]

Aldh1a2 Products(1)

mRNA	Protein	Name
NM_009022.4	NP_033048.2	retinal dehydrogenase 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3-chloroallyl aldehyde dehydrogenase activity	IDA IDA: Inferred from direct assay	12610736	MGI
enables retinal dehydrogenase activity	IDA IDA: Inferred from direct assay	8797830	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within 9-cis-retinoic acid biosynthetic process	IDA IDA: Inferred from direct assay	11876656	MGI
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	17067568	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	15652703	MGI
acts upstream of or within blood vessel development	IMP IMP: Inferred from mutant phenotype	14627725	MGI
acts upstream of or within camera-type eye development	IMP IMP: Inferred from mutant phenotype	15366004	MGI
acts upstream of or within cardiac muscle tissue development	IMP IMP: Inferred from mutant phenotype	9892670	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16368932	MGI
involved in cellular response to retinoic acid	IEP IEP: Inferred from expression pattern	18816858	MGI
acts upstream of or within determination of bilateral symmetry	IMP IMP: Inferred from mutant phenotype	15731404	MGI
acts upstream of or within embryonic camera-type eye development	IGI IGI: Inferred from genetic interaction	17184764	MGI
acts upstream of or within embryonic digestive tract development	IMP IMP: Inferred from mutant phenotype	16806149	MGI
acts upstream of or within embryonic forelimb morphogenesis	IMP IMP: Inferred from mutant phenotype	15069081	MGI
acts upstream of or within embryonic limb morphogenesis	IMP IMP: Inferred from mutant phenotype	14623241	MGI
acts upstream of or within face development	IGI IGI: Inferred from genetic interaction	17184764	MGI
acts upstream of or within face development	IMP IMP: Inferred from mutant phenotype	17184764	MGI
acts upstream of or within forebrain development	IMP IMP: Inferred from mutant phenotype	16368932	MGI
acts upstream of or within heart morphogenesis	IMP IMP: Inferred from mutant phenotype	11245568	MGI
acts upstream of or within hindbrain development	IMP IMP: Inferred from mutant phenotype	15872003	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	16427040	MGI
acts upstream of or within morphogenesis of embryonic epithelium	IMP IMP: Inferred from mutant phenotype	15739227	MGI
acts upstream of or within neural crest cell development	IGI IGI: Inferred from genetic interaction	17067568	MGI
acts upstream of or within neural crest cell development	IMP IMP: Inferred from mutant phenotype	16368932	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	15652703	MGI
acts upstream of or within pancreas development	IMP IMP: Inferred from mutant phenotype	15739227	MGI
acts upstream of or within positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20034106	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16368932	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20034106	MGI
acts upstream of or within proximal/distal pattern formation	IMP IMP: Inferred from mutant phenotype	14623241	MGI
acts upstream of or within regulation of vascular endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	14627725	MGI
acts upstream of or within retinal metabolic process	IDA IDA: Inferred from direct assay	12610736	MGI
acts upstream of or within retinoic acid metabolic process	IDA IDA: Inferred from direct assay	8797830	MGI
acts upstream of or within retinoic acid metabolic process	IMP IMP: Inferred from mutant phenotype	14623241	MGI
acts upstream of or within retinoic acid receptor signaling pathway	IGI IGI: Inferred from genetic interaction	15889094	MGI
acts upstream of or within retinoic acid receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15739227	MGI
acts upstream of or within ureter maturation	IMP IMP: Inferred from mutant phenotype	21521737	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

retinal dehydrogenase 2

RALDH 2	RALDH(II)
alcohol dehydrogenase family 1, subfamily A2	alcohol dehydrogenase family 1, subfamily A7
aldehyde dehydrogenase family 1 member A2	retinaldehyde dehydrogenase 2
retinaldehyde-specific dehydrogenase type 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W011094	Win 18446	Inhibitor	98.94%	Unkown
HY-122912	ALDH1A inhibitor 673A		99.15%	Unkown
HY-135841	CM010	Inhibitor	99.70%	Unkown
HY-125085	ALDH3A1-IN-3	Inhibitor	99.30%	Unkown
HY-157567	FSI-TN42	Inhibitor	98.05%	Unkown
HY-139031	ALDH1A2-IN-1	Inhibitor	98.80%	Unkown
HY-139032	CM121	Inhibitor	/	Unkown
HY-158026	ALDH1A1-IN-5	Inhibitor	/	Unkown
HY-N11451	Lacto-N-fucopentaose III	Activator	/	Unkown
HY-RS00563	ALDH1A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00567	ALDH1L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17028	Aldh1a2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23472	Aldh1a2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Aldh1a2	NCBI	NCBI:8854

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