2. Gene
  3. Abcd3 - ATP-binding cassette, sub-family D (ALD), member 3 Gene

Abcd3 - ATP-binding cassette, sub-family D (ALD), member 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as PMP68; PMP70; Pxmp1

Gene ID: 19299 | Gene type: protein coding

About Abcd3

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. [provided by RefSeq, Jul 2008]

Abcd3 Products(6)

mRNA Protein Name
NM_001355756.2 NP_001342685.1 ATP-binding cassette sub-family D member 3 isoform 2
NM_001409848.1 NP_001396777.1 ATP-binding cassette sub-family D member 3 isoform 3
NM_001409849.1 NP_001396778.1 ATP-binding cassette sub-family D member 3 isoform 4
NM_001409850.1 NP_001396779.1 ATP-binding cassette sub-family D member 3 isoform 5
NM_001409851.1 NP_001396780.1 ATP-binding cassette sub-family D member 3 isoform 2
NM_008991.4 NP_033017.2 ATP-binding cassette sub-family D member 3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19010322 MGI
Biological Process GO Annotation Evidence Reference Source
involved in bile acid and bile salt transport IMP
IMP: Inferred from mutant phenotype
25168382 MGI
involved in bile acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
25168382 MGI
involved in lipid transport IMP
IMP: Inferred from mutant phenotype
25168382 MGI
involved in phytanic acid metabolic process IMP
IMP: Inferred from mutant phenotype
25168382 MGI
Cellular Component GO Annotation Evidence Reference Source
located in peroxisomal membrane IDA
IDA: Inferred from direct assay
12915479 MGI
located in peroxisome IDA
IDA: Inferred from direct assay
19010322 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-binding cassette sub-family D member 3

68 kDa peroxisomal membrane protein

70 kDa peroxisomal membrane protein

peroxisomal membrane protein 1

peroxisomal membrane protein, 70 kDa

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00070 ABCD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03378 CX3CL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16603 Cx3cl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22365 Abcd3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28889 Abcd3 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abcd3 NCBI NCBI:5825