2. Gene
  3. Pspn - persephin Gene

Pspn - persephin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as PSP

Gene ID: 19197 | Gene type: protein coding

About Pspn

Summary

This gene encodes a secreted ligand of the GDNF (glial cell line-derived neurotrophic factor) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. This protein may play a role in cell death, and nervous system development and function. Mice lacking a functional copy of this gene exhibit hypersensitivity to cerebral ischemia. [provided by RefSeq, Aug 2016]

Pspn Products(1)

mRNA Protein Name
NM_008954.4 NP_032980.2 persephin preproprotein
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within branching involved in ureteric bud morphogenesis IDA
IDA: Inferred from direct assay
9491986 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
9491986 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

persephin

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-176305S Neurofilament, U-15N / Unkown
HY-RS11342 PSPN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20802 Pspn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27316 Pspn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pspn NCBI NCBI:5623