P2rx7 - purinergic receptor P2X, ligand-gated ion channel, 7 Gene

Mus musculus

Also known as P2X7R; P2X(7)

Gene ID: 18439 | Gene type: protein coding

About P2rx7

Chromosome 5: 122,781,974-122,829,495 forward strand.GRCm39:CM000998.3

This gene has 8 transcripts (splice variants), 195 orthologues, 6 paralogues and is associated with 27 phenotypes. Ubiquitous expression in subcutaneous fat pad adult (RPKM 4.7), lung adult (RPKM 4.4) and 28 other tissues.

Summary

Enables several functions, including ATP binding activity; extracellularly ATP-gated cation channel activity; and lipopolysaccharide binding activity. Involved in negative regulation of cell volume and sensory perception of pain. Acts upstream of or within several processes, including organophosphate ester transport; positive regulation of cytokine production; and positive regulation of secretion. Located in several cellular components, including external side of plasma membrane; neuromuscular junction; and neuronal cell body. Is integral component of plasma membrane. Is expressed in brain; heart; and metanephros. Orthologous to human P2RX7 (purinergic receptor P2X 7). [provided by Alliance of Genome Resources, Apr 2022]

P2rx7 Products(5)

mRNA	Protein	Name
NM_011027.4	NP_035157.2	P2X purinoceptor 7 isoform a
NM_001284402.2	NP_001271331.1	P2X purinoceptor 7 isoform e
NM_001038839.3	NP_001033928.1	P2X purinoceptor 7 isoform c
NM_001038887.2	NP_001033976.1	P2X purinoceptor 7 isoform d
NM_001038845.3	NP_001033934.1	P2X purinoceptor 7 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IMP IMP: Inferred from mutant phenotype	12677010	MGI
enables channel activity	IMP IMP: Inferred from mutant phenotype	18519738	MGI
enables extracellularly ATP-gated monoatomic cation channel activity	IMP IMP: Inferred from mutant phenotype	12677010	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	15713258	MGI
enables lipopolysaccharide binding	IDA IDA: Inferred from direct assay	11489964	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15331634	MGI
enables signaling receptor activity	IMP IMP: Inferred from mutant phenotype	12677010	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of MAPK cascade	IMP IMP: Inferred from mutant phenotype	15937334	MGI
acts upstream of or within NAD transport	IMP IMP: Inferred from mutant phenotype	17803959	MGI
acts upstream of T cell apoptotic process	IMP IMP: Inferred from mutant phenotype	16325464	MGI
acts upstream of or within T cell homeostasis	IMP IMP: Inferred from mutant phenotype	16116196	MGI
acts upstream of T cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	14761980	MGI
acts upstream of or within T cell proliferation	IMP IMP: Inferred from mutant phenotype	15914561	MGI
acts upstream of or within bleb assembly	IMP IMP: Inferred from mutant phenotype	17135244	MGI
involved in bleb assembly	IMP IMP: Inferred from mutant phenotype	25651887	MGI
acts upstream of or within calcium ion transport	IMP IMP: Inferred from mutant phenotype	12370338	MGI
acts upstream of or within cell morphogenesis	IMP IMP: Inferred from mutant phenotype	12055263	MGI
acts upstream of or within cell volume homeostasis	IDA IDA: Inferred from direct assay	18097031	MGI
acts upstream of or within cellular response to dsRNA	IMP IMP: Inferred from mutant phenotype	24114535	MGI
acts upstream of or within cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	23479225	MGI
acts upstream of or within cellular response to stimulus	IMP IMP: Inferred from mutant phenotype	18082965	MGI
acts upstream of or within ceramide biosynthetic process	IDA IDA: Inferred from direct assay	16325464	MGI
acts upstream of or within collagen metabolic process	IMP IMP: Inferred from mutant phenotype	16969386	MGI
acts upstream of or within defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	11544318	MGI
acts upstream of establishment of localization in cell	IDA IDA: Inferred from direct assay	15240711	MGI
acts upstream of or within establishment of localization in cell	IDA IDA: Inferred from direct assay	18097031	MGI
acts upstream of establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	16269410	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	12370338	MGI
acts upstream of or within extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	17286969	MGI
acts upstream of gamma-aminobutyric acid secretion	IMP IMP: Inferred from mutant phenotype	15640761	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	18519738	MGI
acts upstream of glutamate secretion	IMP IMP: Inferred from mutant phenotype	15640761	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IMP IMP: Inferred from mutant phenotype	16969386	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	12055263	MGI
acts upstream of interleukin-1 alpha production	IMP IMP: Inferred from mutant phenotype	18490713	MGI
acts upstream of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	11016935	MGI
acts upstream of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	11016935	MGI
acts upstream of lymphocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	16493071	MGI
acts upstream of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	11016935	MGI
acts upstream of or within membrane protein ectodomain proteolysis	IMP IMP: Inferred from mutant phenotype	17286969	MGI
acts upstream of mitochondrial depolarization	IMP IMP: Inferred from mutant phenotype	16198349	MGI
acts upstream of or within mitochondrion organization	IDA IDA: Inferred from direct assay	16325464	MGI
acts upstream of or within monoatomic cation transport	IMP IMP: Inferred from mutant phenotype	12677010	MGI
acts upstream of or within negative regulation of MAPK cascade	IDA IDA: Inferred from direct assay	11489964	MGI
acts upstream of or within negative regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	12677010	MGI
involved in negative regulation of cell volume	IMP IMP: Inferred from mutant phenotype	25651887	MGI
acts upstream of or within phagolysosome assembly	IMP IMP: Inferred from mutant phenotype	11544318	MGI
acts upstream of or within phospholipid transfer to membrane	IMP IMP: Inferred from mutant phenotype	12370338	MGI
acts upstream of or within phospholipid translocation	IDA IDA: Inferred from direct assay	18097031	MGI
acts upstream of or within plasma membrane organization	IDA IDA: Inferred from direct assay	18097031	MGI
acts upstream of or within pore complex assembly	IMP IMP: Inferred from mutant phenotype	12370338	MGI
acts upstream of or within positive regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	17306762	MGI
acts upstream of or within positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	15937334	MGI
acts upstream of or within positive regulation of T cell apoptotic process	IMP IMP: Inferred from mutant phenotype	16325464	MGI
acts upstream of or within positive regulation of T cell mediated cytotoxicity	IMP IMP: Inferred from mutant phenotype	14761980	MGI
acts upstream of or within positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16969386	MGI
acts upstream of or within positive regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	12677010	MGI
acts upstream of or within positive regulation of catalytic activity	IMP IMP: Inferred from mutant phenotype	14761980	MGI
acts upstream of or within positive regulation of gamma-aminobutyric acid secretion	IMP IMP: Inferred from mutant phenotype	15640761	MGI
acts upstream of or within positive regulation of glutamate secretion	IMP IMP: Inferred from mutant phenotype	15640761	MGI
acts upstream of or within positive regulation of interleukin-1 alpha production	IMP IMP: Inferred from mutant phenotype	18490713	MGI
acts upstream of or within positive regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	11016935	MGI
acts upstream of or within positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	11016935	MGI
acts upstream of or within positive regulation of lymphocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	16493071	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	11016935	MGI
acts upstream of or within positive regulation of mitochondrial depolarization	IMP IMP: Inferred from mutant phenotype	16198349	MGI
acts upstream of or within positive regulation of ossification	IMP IMP: Inferred from mutant phenotype	16269410	MGI
acts upstream of or within positive regulation of prostaglandin secretion	IMP IMP: Inferred from mutant phenotype	16269410	MGI
acts upstream of or within positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	15937334	MGI
acts upstream of or within positive regulation of protein secretion	IDA IDA: Inferred from direct assay	15240711	MGI
acts upstream of or within programmed cell death	IDA IDA: Inferred from direct assay	16116196	MGI
acts upstream of or within programmed cell death	IMP IMP: Inferred from mutant phenotype	14761980	MGI
acts upstream of prostaglandin secretion	IMP IMP: Inferred from mutant phenotype	16269410	MGI
acts upstream of or within protein catabolic process	IDA IDA: Inferred from direct assay	11489964	MGI
acts upstream of or within protein phosphorylation	IMP IMP: Inferred from mutant phenotype	17306762	MGI
acts upstream of or within protein processing	IMP IMP: Inferred from mutant phenotype	11016935	MGI
acts upstream of protein secretion	IDA IDA: Inferred from direct assay	15240711	MGI
acts upstream of or within reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	17448897	MGI
acts upstream of or within release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	18082965	MGI
acts upstream of or within response to ATP	IDA IDA: Inferred from direct assay	15240711	MGI
acts upstream of or within response to ATP	IMP IMP: Inferred from mutant phenotype	11016935	MGI
acts upstream of or within response to bacterium	IMP IMP: Inferred from mutant phenotype	10395640	MGI
acts upstream of or within response to calcium ion	IDA IDA: Inferred from direct assay	15240711	MGI
acts upstream of or within response to calcium ion	IMP IMP: Inferred from mutant phenotype	15978588	MGI
acts upstream of or within response to electrical stimulus	IMP IMP: Inferred from mutant phenotype	15640761	MGI
acts upstream of or within response to fluid shear stress	IMP IMP: Inferred from mutant phenotype	16269410	MGI
acts upstream of or within response to lipopolysaccharide	IDA IDA: Inferred from direct assay	15240711	MGI
acts upstream of or within response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	12055263	MGI
acts upstream of or within response to mechanical stimulus	IMP IMP: Inferred from mutant phenotype	16269410	MGI
acts upstream of or within response to organic cyclic compound	IDA IDA: Inferred from direct assay	15240711	MGI
acts upstream of or within response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	18082965	MGI
acts upstream of or within response to zinc ion	IMP IMP: Inferred from mutant phenotype	15978588	MGI
involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	15777864	MGI
acts upstream of or within skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	18519738	MGI
acts upstream of or within synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	15713258	MGI
acts upstream of or within vesicle budding from membrane	IMP IMP: Inferred from mutant phenotype	15905573	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell-cell junction	IDA IDA: Inferred from direct assay	15331634	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	17286969	MGI
located in membrane	IDA IDA: Inferred from direct assay	15713258	MGI
located in neuromuscular junction	IDA IDA: Inferred from direct assay	15713258	MGI
is active in neuromuscular junction	IPI IPI: Inferred from physical interaction	15713258	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	15964665	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15331634	MGI
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	12677010	MGI
located in synapse	IDA IDA: Inferred from direct assay	18082965	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2rx7 Protein Structure

P2X_receptor

0
100
200
300
400
500
595 a.a.

Protein Preferred Names

Protein Names

P2X purinoceptor 7

ATP receptor	P2X7 purinoceptor
P2X7 receptor	P2Z receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09911	P2RX7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09912	P2rx7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09913	P2RX7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	P2rx7	NCBI	NCBI:5027

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