2. Gene
  3. Numb - NUMB endocytic adaptor protein Gene

Numb - NUMB endocytic adaptor protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Nb

Gene ID: 18222 | Gene type: protein coding

About Numb

Summary

This gene encodes a conserved protein that is distributed asymmetrically during cell division in the developing embryo. The encoded protein participates in cell fate decisions by interacting with the Notch receptor. Loss of function of this gene results in severe defects in neural development and loss of viability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Numb Products(8)

mRNA Protein Name
NM_001136075.3 NP_001129547.1 protein numb homolog isoform 1
NM_001272055.2 NP_001258984.1 protein numb homolog isoform 3
NM_001272056.1 NP_001258985.1 protein numb homolog isoform 4
NM_001411949.1 NP_001398878.1 protein numb homolog isoform 1
NM_001411950.1 NP_001398879.1 protein numb homolog isoform 2
NM_001411951.1 NP_001398880.1 protein numb homolog isoform 4
NM_001411952.1 NP_001398881.1 protein numb homolog isoform 3
NM_010949.3 NP_035079.1 protein numb homolog isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables alpha-catenin binding IPI
IPI: Inferred from physical interaction
17589506 MGI
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
17589506 MGI
enables cadherin binding IPI
IPI: Inferred from physical interaction
17589506 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11922143 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within adherens junction organization IGI
IGI: Inferred from genetic interaction
17589506 MGI
acts upstream of or within axonogenesis IDA
IDA: Inferred from direct assay
15598981 MGI
acts upstream of or within axonogenesis IMP
IMP: Inferred from mutant phenotype
15598981 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
14687546 MGI
involved in lateral ventricle development IMP
IMP: Inferred from mutant phenotype
17174898 MGI
acts upstream of or within nervous system development IMP
IMP: Inferred from mutant phenotype
10841580 MGI
involved in neuroblast division in subventricular zone IMP
IMP: Inferred from mutant phenotype
17174898 MGI
acts upstream of or within neuroblast proliferation IGI
IGI: Inferred from genetic interaction
12410312 MGI
involved in positive regulation of neurogenesis IMP
IMP: Inferred from mutant phenotype
12410312 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: Inferred from direct assay
26621723 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IEP
IEP: Inferred from expression pattern
26621723 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IMP
IMP: Inferred from mutant phenotype
26621723 MGI
Cellular Component GO Annotation Evidence Reference Source
located in apical part of cell IDA
IDA: Inferred from direct assay
12361975 MGI
NOT located in apical plasma membrane IDA
IDA: Inferred from direct assay
17589506 MGI
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
17589506 MGI
located in clathrin-coated pit IDA
IDA: Inferred from direct assay
26437238 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
22174158 MGI
located in early endosome IDA
IDA: Inferred from direct assay
11782429 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
26621723 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
26621723 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
26621723 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein numb homolog

numb gene homolog

numb homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-119734 Gossypolone 96.63% Unkown
HY-N7013 Hydroxy-Epsilon-Sanshool / Unkown
HY-N7014 Hydroxyl-​γ-​isosanshool / Unkown
HY-RS09681 NUMB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19926 Numb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26428 Numb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Numb NCBI NCBI:8650