Uhrf1 - ubiquitin-like, containing PHD and RING finger domains, 1 Gene

Mus musculus

Also known as Np95; ICBP90; RNF106

Gene ID: 18140 | Gene type: protein coding

About Uhrf1

Summary

Enables several functions, including hemi-methylated DNA-binding activity; histone binding activity; and ubiquitin protein Ligase activity. Involved in maintenance of DNA methylation; negative regulation of transcription by RNA polymerase II; and protein ubiquitination. Located in heterochromatin; nuclear matrix; and replication fork. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hindlimb phalanx; and sensory organ. Orthologous to human UHRF1 (ubiquitin like with PHD and ring finger domains 1). [provided by Alliance of Genome Resources, Apr 2022]

Uhrf1 Products(8)

mRNA	Protein	Name
NM_001111078.2	NP_001104548.1	E3 ubiquitin-protein ligase UHRF1 isoform A
NM_001111079.2	NP_001104549.1	E3 ubiquitin-protein ligase UHRF1 isoform B
NM_001111080.2	NP_001104550.1	E3 ubiquitin-protein ligase UHRF1 isoform B
NM_001413357.1	NP_001400286.1	E3 ubiquitin-protein ligase UHRF1 isoform C
NM_001413358.1	NP_001400287.1	E3 ubiquitin-protein ligase UHRF1 isoform D
NM_001413359.1	NP_001400288.1	E3 ubiquitin-protein ligase UHRF1 isoform E
NM_001413360.1	NP_001400289.1	E3 ubiquitin-protein ligase UHRF1 isoform D
NM_010931.4	NP_035061.3	E3 ubiquitin-protein ligase UHRF1 isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables hemi-methylated DNA-binding	IDA IDA: Inferred from direct assay	17994007	MGI
enables histone H3 ubiquitin ligase activity	IDA IDA: Inferred from direct assay	14993289	MGI
enables histone binding	IDA IDA: Inferred from direct assay	14993289	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	14993289	MGI
enables methylated histone binding	IDA IDA: Inferred from direct assay	21489993	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	17994007	MGI
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	14993289	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of gene expression via chromosomal CpG island methylation	IMP IMP: Inferred from mutant phenotype	17673620	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21489993	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	14993289	MGI
located in heterochromatin	IDA IDA: Inferred from direct assay	17994007	MGI
located in nuclear matrix	IDA IDA: Inferred from direct assay	14993289	MGI
located in nucleus	IDA IDA: Inferred from direct assay	17994007	MGI
located in replication fork	IDA IDA: Inferred from direct assay	17994007	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase UHRF1

RING-type E3 ubiquitin transferase UHRF1	mUhrf1
nuclear protein 95	nuclear zinc finger protein Np95
ubiquitin-like PHD and RING finger domain-containing protein 1	ubiquitin-like-containing PHD and RING finger domains protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125292	NV03		99.77%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Uhrf1	NCBI	NCBI:29128

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