Nek2 - NIMA (never in mitosis gene a)-related expressed kinase 2 Gene

Mus musculus

Gene ID: 18005 | Gene type: protein coding

About Nek2

Summary

Enables protein kinase activity. Acts upstream of or within several processes, including blastocyst development; mitotic nuclear division; and negative regulation of DNA binding activity. Located in condensed nuclear chromosome; midbody; and spindle pole. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and respiratory system. Human ortholog(s) of this gene implicated in retinitis pigmentosa 67. Orthologous to human NEK2 (NIMA related kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Nek2 Products(2)

mRNA	Protein	Name
NM_010892.3	NP_035022.2	serine/threonine-protein kinase Nek2
NM_010892.3	NP_035022.2	serine/threonine-protein kinase Nek2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14668482	MGI
enables protein kinase activity	IDA IDA: Inferred from direct assay	14668482	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within blastocyst development	IMP IMP: Inferred from mutant phenotype	19117032	MGI
acts upstream of or within chromosome segregation	IMP IMP: Inferred from mutant phenotype	19117032	MGI
acts upstream of or within mitotic sister chromatid segregation	IMP IMP: Inferred from mutant phenotype	15479717	MGI
acts upstream of or within mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	19117032	MGI
acts upstream of or within negative regulation of DNA binding	IDA IDA: Inferred from direct assay	14668482	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	14697346	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in condensed nuclear chromosome	IDA IDA: Inferred from direct assay	15479717	MGI
located in midbody	IDA IDA: Inferred from direct assay	15479717	MGI
located in spindle pole	IDA IDA: Inferred from direct assay	15479717	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

serine/threonine-protein kinase Nek2

NIMA - related expressed kinase 2	NIMA-related expressed kinase 2
NIMA-related kinase 2	Nek2 kinase
never in mitosis A-related kinase 2	nimA-related protein kinase 2

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-120356A	T-1101 tosylate	Inhibitor	98.91%	Phase 1

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117154	INH154		99.89%	Unkown
HY-16660	INH1	Inhibitor	99.85%	Unkown
HY-101029	MBM-55	Inhibitor	99.94%	Unkown
HY-116423	JH295		98.66%	Unkown
HY-156437	NBI-961	Inhibitor	99.73%	Unkown
HY-100541	INH6	Inhibitor	99.53%	Unkown
HY-B0790	TAI-1	Inhibitor	98.02%	Unkown
HY-101030A	MBM-17S	Inhibitor	/	Unkown
HY-137046	Nek2-IN-4		/	Unkown
HY-116423A	JH295 hydrate		≥99.0%	Unkown
HY-153749	Nek2/Hec1-IN-2		≥98.0%	Unkown
HY-101029A	MBM-55S	Inhibitor	/	Unkown
HY-101030	MBM-17	Inhibitor	/	Unkown
HY-150046	Nek2-IN-6		/	Unkown
HY-120356	T-1101	Inhibitor	/	Unkown
HY-120330	Nek2-IN-5		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nek2	NCBI	NCBI:4751

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