2. Gene
  3. Ncf2 - neutrophil cytosolic factor 2 Gene

Ncf2 - neutrophil cytosolic factor 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as NOXA2; Ncf-2; p67phox

Gene ID: 17970 | Gene type: protein coding

About Ncf2

Summary

Enables small GTPase binding activity. Contributes to superoxide-generating NAD(P)H oxidase activity. Acts upstream of or within superoxide anion generation. Located in acrosomal vesicle. Is expressed in several structures, including hemolymphoid system; limb; and liver. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal recessive chronic granulomatous disease cytochrome b-positive type II; and rheumatoid arthritis. Orthologous to human NCF2 (neutrophil cytosolic factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ncf2 Products(1)

mRNA Protein Name
NM_010877.5 NP_035007.1 neutrophil cytosol factor 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
9490028 MGI
enables small GTPase binding IPI
IPI: Inferred from physical interaction
9490028 MGI
contributes to superoxide-generating NAD(P)H oxidase activity IDA
IDA: Inferred from direct assay
9490028 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within superoxide anion generation IDA
IDA: Inferred from direct assay
9490028 MGI
Cellular Component GO Annotation Evidence Reference Source
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
15850784 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15850784 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neutrophil cytosol factor 2

67 kDa neutrophil oxidase factor

NADPH oxidase activator 2

NADPH oxidase subunit (67kDa)

neutrophil NADPH oxidase factor 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09078 NCF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19358 Ncf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25849 Ncf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ncf2 NCBI NCBI:4688