2. Gene
  3. Commd1 - COMM domain containing 1 Gene

Commd1 - COMM domain containing 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Murr1; U2/Mu

Gene ID: 17846 | Gene type: protein coding

About Commd1

Summary

Predicted to enable several functions, including low-density lipoprotein particle receptor binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and phospholipid binding activity. Acts upstream of or within several processes, including Cholesterol homeostasis; low-density lipoprotein particle clearance; and positive regulation of protein localization. Located in endosome. Is expressed in several structures, including central nervous system; extraembryonic component; future brain; limb bud; and otocyst. Orthologous to human COMMD1 (copper metabolism domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Commd1 Products(2)

mRNA Protein Name
NM_001361661.1 NP_001348590.1 COMM domain-containing protein 1 isoform 2
NM_144514.2 NP_653097.2 COMM domain-containing protein 1 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17371845 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
26965651 MGI
acts upstream of or within low-density lipoprotein particle clearance IMP
IMP: Inferred from mutant phenotype
26965651 MGI
acts upstream of or within negative regulation of hypoxia-inducible factor-1alpha signaling pathway IMP
IMP: Inferred from mutant phenotype
17371845 MGI
acts upstream of or within positive regulation of cholesterol import IMP
IMP: Inferred from mutant phenotype
26965651 MGI
acts upstream of or within positive regulation of endosome to plasma membrane protein transport IMP
IMP: Inferred from mutant phenotype
26965651 MGI
acts upstream of or within positive regulation of protein localization to cell surface IMP
IMP: Inferred from mutant phenotype
26965651 MGI
acts upstream of or within protein destabilization IMP
IMP: Inferred from mutant phenotype
17371845 MGI
acts upstream of protein localization to cell surface IMP
IMP: Inferred from mutant phenotype
26965651 MGI
acts upstream of or within regulation of plasma lipoprotein particle levels IMP
IMP: Inferred from mutant phenotype
26965651 MGI
Cellular Component GO Annotation Evidence Reference Source
located in endosome IDA
IDA: Inferred from direct assay
26965651 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

COMM domain-containing protein 1

U2af1-rs1 region 1

copper metabolism domain containing 1

protein Murr1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03009 COMMD1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21109 Commd1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27628 Commd1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Commd1 NCBI NCBI:150684