1. Gene
  2. Msh6 - mutS homolog 6 Gene

Msh6 - mutS homolog 6 Gene

Mus musculus

Also known as GTBP; Gtmbp

Gene ID: 17688 | Gene type: protein coding

About Msh6

Summary

Enables chromatin binding activity; damaged DNA binding activity; and guanine/thymine mispair binding activity. Acts upstream of or within several processes, including determination of adult lifespan; intrinsic apoptotic signaling pathway in response to DNA damage; and somatic diversification of immunoglobulins. Located in chromatin. Part of MutSalpha complex. Is expressed in several structures, including brain; early conceptus; liver; lung; and oocyte. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal carcinoma; endometrial cancer; hereditary nonpolyposis colorectal Cancer type 5; and mismatch repair Cancer syndrome. Orthologous to human MSH6 (mutS homolog 6). [provided by Alliance of Genome Resources, Apr 2022]

Msh6 Products(1)

mRNA Protein Name
NM_010830.2 NP_034960.1 DNA mismatch repair protein Msh6
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IGI
IGI: Inferred from genetic interaction
10545954 MGI
enables DNA binding IMP
IMP: Inferred from mutant phenotype
10545954 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
16618598 MGI
enables damaged DNA binding IGI
IGI: Inferred from genetic interaction
10545954 MGI
enables damaged DNA binding IMP
IMP: Inferred from mutant phenotype
10545954 MGI
contributes to guanine/thymine mispair binding IDA
IDA: Inferred from direct assay
16713580 MGI
enables guanine/thymine mispair binding IDA
IDA: Inferred from direct assay
15324697 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within determination of adult lifespan IMP
IMP: Inferred from mutant phenotype
9390556 MGI
acts upstream of or within intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
14632208 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: Inferred from mutant phenotype
15324697 MGI
acts upstream of or within isotype switching IGI
IGI: Inferred from genetic interaction
17015724 MGI
acts upstream of or within isotype switching IMP
IMP: Inferred from mutant phenotype
16618598 MGI
acts upstream of or within mismatch repair IGI
IGI: Inferred from genetic interaction
11691815 MGI
acts upstream of or within mismatch repair IMP
IMP: Inferred from mutant phenotype
9390556 MGI
acts upstream of or within negative regulation of DNA recombination IMP
IMP: Inferred from mutant phenotype
10545954 MGI
acts upstream of or within response to UV IMP
IMP: Inferred from mutant phenotype
14632208 MGI
acts upstream of or within somatic hypermutation of immunoglobulin genes IMP
IMP: Inferred from mutant phenotype
10662804 MGI
acts upstream of or within somatic recombination of immunoglobulin gene segments IMP
IMP: Inferred from mutant phenotype
15238604 MGI
Cellular Component GO Annotation Evidence Reference Source
part of MutSalpha complex IDA
IDA: Inferred from direct assay
16713580 MGI
located in chromatin IDA
IDA: Inferred from direct assay
16618598 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA mismatch repair protein Msh6

g/T mismatch-binding protein

mutS protein homolog 6

mutS-alpha 160 kDa subunit

p160

Orthologs Information

Species Symbol Source ID
Homo sapiens Msh6 NCBI NCBI:2956