2. Gene
  3. Mdh1 - malate dehydrogenase 1, NAD (soluble) Gene

Mdh1 - malate dehydrogenase 1, NAD (soluble) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as KAR; MDHA; Mor2; MDH-s; Mor-2; B230377B03Rik

Gene ID: 17449 | Gene type: protein coding

About Mdh1

Summary

This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the Other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. A pseudogene has been identified on chromosomes 12. [provided by RefSeq, Feb 2016]

Mdh1 Products(2)

mRNA Protein Name
NM_001316675.1 NP_001303604.1 malate dehydrogenase, peroxisomal isoform Mdh1x
NM_008618.3 NP_032644.3 malate dehydrogenase, cytoplasmic isoform Mdh1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables L-malate dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
5770240 MGI
enables L-malate dehydrogenase (NAD+) activity IMP
IMP: Inferred from mutant phenotype
7698769 MGI
Biological Process GO Annotation Evidence Reference Source
involved in malate-aspartate shuttle IMP
IMP: Inferred from mutant phenotype
32396938 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in cytosol IDA
IDA: Inferred from direct assay
5770240 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

malate dehydrogenase, cytoplasmic

malate dehydrogenase, peroxisomal

aromatic alpha-keto acid reductase

cytosolic malate dehydrogenase

malate dehydrogenase, soluble

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-147791 MDH1-IN-2 Inhibitor 98.70% Unkown
HY-147790 MDH1-IN-1 99.97% Unkown
HY-W613220 MDH1/2-IN-1 Inhibitor 99.53% Unkown
HY-RS08260 MDH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16793 Mdh1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17185 Me1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23233 Mdh1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mdh1 NCBI NCBI:4190
Rattus norvegicus Mdh1 NCBI NCBI:24551