2. Gene
  3. Mdh2 - malate dehydrogenase 2, NAD (mitochondrial) Gene

Mdh2 - malate dehydrogenase 2, NAD (mitochondrial) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as MDH; Mor1; Mdh-2; Mor-1

Gene ID: 17448 | Gene type: protein coding

About Mdh2

Summary

Enables L-malate dehydrogenase activity. Predicted to be involved in NADH metabolic process; dicarboxylic acid metabolic process; and tricarboxylic acid cycle. Located in membrane. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 51. Orthologous to human MDH2 (malate dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]

Mdh2 Products(1)

mRNA Protein Name
NM_008617.2 NP_032643.2 malate dehydrogenase, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables L-malate dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
1203052 MGI
Biological Process GO Annotation Evidence Reference Source
involved in gluconeogenesis IDA
IDA: Inferred from direct assay
12581790 MGI
involved in malate-aspartate shuttle IDA
IDA: Inferred from direct assay
24134846 MGI
involved in tricarboxylic acid cycle IDA
IDA: Inferred from direct assay
35063410 MGI
Cellular Component GO Annotation Evidence Reference Source
located in membrane IMP
IMP: Inferred from mutant phenotype
20080761 MGI
is active in mitochondrial matrix IDA
IDA: Inferred from direct assay
5496232 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

malate dehydrogenase, mitochondrial

mitochondrial malate dehydrogenase 2, NAD

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13671 LW6 98.47% Unkown
HY-147791 MDH1-IN-2 Inhibitor 98.70% Unkown
HY-RS08261 MDH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16896 Mdh2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23338 Mdh2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mdh2 NCBI NCBI:4191