2. Gene
  3. Mmp11 - matrix metallopeptidase 11 Gene

Mmp11 - matrix metallopeptidase 11 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ST3; SL-3; Stmy3; MMP-11

Gene ID: 17385 | Gene type: protein coding

About Mmp11

Summary

This gene encodes a member of the matrix metalloproteinase family of endopeptidases that are involved in remodeling extracellular matrix during, for example, embryonic development and tumor progression. The encoded protein undergoes post-translational proteolytic processing by Furin endopeptidase to form an active enzyme. Subcutaneous introduction of cells expressing the encoded protein into nude mice results in increased tumor incidence. Mice lacking the encoded protein exhibit a decreased incidence of chemically-induced tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Mmp11 Products(2)

mRNA Protein Name
NM_001306184.1 NP_001293113.1 stromelysin-3 preproprotein
NM_008606.3 NP_032632.1 stromelysin-3 preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables metallopeptidase activity IDA
IDA: Inferred from direct assay
18622425 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within basement membrane organization IMP
IMP: Inferred from mutant phenotype
18622425 MGI
acts upstream of or within collagen catabolic process IDA
IDA: Inferred from direct assay
18622425 MGI
acts upstream of or within collagen fibril organization IMP
IMP: Inferred from mutant phenotype
18622425 MGI
acts upstream of or within extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
18622425 MGI
acts upstream of or within negative regulation of fat cell differentiation IDA
IDA: Inferred from direct assay
18622425 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

stromelysin-3

matrix metalloproteinase 11

stromelysin 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-162038 RXP03 Inhibitor 98.82% Unkown
HY-162039 MMP-11-IN-1 / Unkown
HY-RS08521 MMP11 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19717 Mmp11 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26213 Mmp11 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp11 NCBI NCBI:4320