Men1 - multiple endocrine neoplasia 1 Gene

Mus musculus

Gene ID: 17283 | Gene type: protein coding

About Men1

Summary

Enables DNA-binding transcription activator activity; chromatin binding activity; and transcription cis-regulatory region binding activity. Involved in histone H3-K4 methylation. Acts upstream of or within several processes, including osteoblast development; positive regulation of macromolecule metabolic process; and regulation of osteoblast differentiation. Located in chromosome, telomeric region; cytoplasm; and nucleus. Is expressed in several structures, including 1st branchial arch; alimentary system; central nervous system; gonad; and sensory organ. Used to study growth hormone secreting pituitary adenoma; hyperparathyroidism; multiple endocrine neoplasia type 1; and prolactinoma. Human ortholog(s) of this gene implicated in endocrine gland Cancer (multiple); hyperparathyroidism; and multiple endocrine neoplasia type 1. Orthologous to human MEN1 (menin 1). [provided by Alliance of Genome Resources, Apr 2022]

Men1 Products(4)

mRNA	Protein	Name
NM_001168488.1	NP_001161960.1	menin isoform a
NM_001168489.1	NP_001161961.1	menin isoform b
NM_001168490.1	NP_001161962.1	menin isoform c
NM_008583.2	NP_032609.1	menin isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	14992727	MGI
enables DNA-binding transcription activator activity	IDA IDA: Inferred from direct assay	14992727	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	15640349	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15150273	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20956546	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	14992727	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of cell division	IMP IMP: Inferred from mutant phenotype	16195383	MGI
acts upstream of cell population proliferation	IDA IDA: Inferred from direct assay	17975067	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	17409423	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12941803	MGI
acts upstream of or within chromatin remodeling	IGI IGI: Inferred from genetic interaction	16415155	MGI
acts upstream of or within chromatin remodeling	IMP IMP: Inferred from mutant phenotype	15044367	MGI
acts upstream of or within embryo development	IMP IMP: Inferred from mutant phenotype	11158604	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	17927973	MGI
acts upstream of fibroblast apoptotic process	IDA IDA: Inferred from direct assay	14688275	MGI
acts upstream of fibroblast apoptotic process	IGI IGI: Inferred from genetic interaction	14688275	MGI
acts upstream of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	15640349	MGI
acts upstream of or within hemopoiesis	IMP IMP: Inferred from mutant phenotype	16415155	MGI
acts upstream of or within leukocyte homeostasis	IMP IMP: Inferred from mutant phenotype	16415155	MGI
acts upstream of or within maternal process involved in female pregnancy	IDA IDA: Inferred from direct assay	17975067	MGI
acts upstream of or within negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15044367	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	11158604	MGI
acts upstream of or within negative regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	15640349	MGI
acts upstream of or within negative regulation of organ growth	IDA IDA: Inferred from direct assay	17975067	MGI
acts upstream of or within negative regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	15150273	MGI
acts upstream of or within negative regulation of osteoblast differentiation	IGI IGI: Inferred from genetic interaction	15563473	MGI
acts upstream of or within negative regulation of stem cell proliferation	IGI IGI: Inferred from genetic interaction	17409423	MGI
acts upstream of or within negative regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	17927973	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15044367	MGI
acts upstream of or within negative regulation of type B pancreatic cell proliferation	IDA IDA: Inferred from direct assay	17975067	MGI
acts upstream of or within negative regulation of type B pancreatic cell proliferation	IMP IMP: Inferred from mutant phenotype	12941803	MGI
acts upstream of organ growth	IDA IDA: Inferred from direct assay	17975067	MGI
acts upstream of or within ossification	IMP IMP: Inferred from mutant phenotype	17927973	MGI
acts upstream of or within osteoblast development	IGI IGI: Inferred from genetic interaction	15150273	MGI
acts upstream of or within osteoblast fate commitment	IGI IGI: Inferred from genetic interaction	15150273	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14992727	MGI
acts upstream of or within positive regulation of cell division	IMP IMP: Inferred from mutant phenotype	16195383	MGI
acts upstream of or within positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	14688275	MGI
acts upstream of or within positive regulation of fibroblast apoptotic process	IDA IDA: Inferred from direct assay	14688275	MGI
acts upstream of or within positive regulation of fibroblast apoptotic process	IGI IGI: Inferred from genetic interaction	14688275	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	14992727	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16195383	MGI
acts upstream of or within positive regulation of osteoblast differentiation	IGI IGI: Inferred from genetic interaction	15150273	MGI
acts upstream of or within positive regulation of stem cell differentiation	IMP IMP: Inferred from mutant phenotype	17927973	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16195383	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15150273	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16415155	MGI
acts upstream of or within regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	16740708	MGI
acts upstream of or within regulation of gene expression	IDA IDA: Inferred from direct assay	24824656	MGI
acts upstream of or within roof of mouth development	IMP IMP: Inferred from mutant phenotype	17927973	MGI
acts upstream of stem cell differentiation	IMP IMP: Inferred from mutant phenotype	17927973	MGI
acts upstream of stem cell proliferation	IGI IGI: Inferred from genetic interaction	17409423	MGI
acts upstream of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	17927973	MGI
involved in transcription initiation-coupled chromatin remodeling	IMP IMP: Inferred from mutant phenotype	14992727	MGI
acts upstream of type B pancreatic cell proliferation	IDA IDA: Inferred from direct assay	17975067	MGI
acts upstream of type B pancreatic cell proliferation	IMP IMP: Inferred from mutant phenotype	12941803	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	12203793	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	9824159	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9824159	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

menin

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-151595	Menin-MLL inhibitor-22	Inhibitor	99.85%	Unkown
HY-103304	CGRP antagonist 4	Antagonist	/	Unkown
HY-168182	Menin-MLL inhibitor 34	Inhibitor	/	Unkown
HY-172416	Balomenib	Inhibitor	/	Unkown
HY-RS08333	MEN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-177140	CDD-1147	Inhibitor	/	Unkown
HY-RS18140	Men1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24615	Men1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Men1	NCBI	NCBI:4221

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