Abcc1 - ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Gene

Mus musculus

Also known as MRP; Mrp1; Mdrap; Abcc1a; Abcc1b

Gene ID: 17250 | Gene type: protein coding

About Abcc1

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein plays an essential role in the defense against toxic compounds and serves as the major high-affinity transporter of leukotriene C4. The encoded protein may also play an essential role in steroid hormone homeostasis as a transporter for steroid Hormones and their metabolites. [provided by RefSeq, Nov 2011]

Abcc1 Products(1)

mRNA	Protein	Name
NM_008576.3	NP_032602.1	multidrug resistance-associated protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ABC-type glutathione S-conjugate transporter activity	IMP IMP: Inferred from mutant phenotype	9359705	MGI
enables ABC-type vitamin B12 transporter activity	IMP IMP: Inferred from mutant phenotype	19897579	MGI
enables efflux transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	26200696	MGI
enables glutathione transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	26200696	MGI
enables xenobiotic transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	26200696	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to amyloid-beta	IMP IMP: Inferred from mutant phenotype	26200696	MGI
involved in cobalamin transport	IMP IMP: Inferred from mutant phenotype	19897579	MGI
involved in cyclic nucleotide transport	IMP IMP: Inferred from mutant phenotype	36070769	MGI
involved in export across plasma membrane	IMP IMP: Inferred from mutant phenotype	26200696	MGI
involved in leukotriene transport	IMP IMP: Inferred from mutant phenotype	9359705	MGI
involved in positive regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	9359705	MGI
involved in response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	9359705	MGI
involved in xenobiotic transport	IMP IMP: Inferred from mutant phenotype	26200696	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in basal plasma membrane	IMP IMP: Inferred from mutant phenotype	19897579	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12951053	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

multidrug resistance-associated protein 1

ATP-binding cassette, sub-family C (CFTR/MRP), member 1a	ATP-binding cassette, sub-family C (CFTR/MRP), member 1b
LTC4 transporter	glutathione-S-conjugate-translocating ATPase ABCC1
leukotriene C(4) transporter	multiple drug resistance-associated pro

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1794	Thiethylperazine		99.91%	Unkown
HY-B1794A	Thiethylperazine dimaleate		99.99%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-17013A	Dofequidar fumarate	Inhibitor	≥98.0%	Phase 3
HY-17013D	Dofequidar sesquifumarate	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19989A	MK-571 sodium		99.75%	Unkown
HY-19989	MK-571		98.85%	Unkown
HY-101453	Ceefourin 1	Inhibitor	99.72%	Unkown
HY-N3610	Coclaurine	Antagonist	98.97%	Unkown
HY-17013	Dofequidar	Inhibitor	98.17%	Unkown
HY-113805	MC70	Inhibitor	99.50%	Unkown
HY-D1609	BODIPY FL Verapamil hydrochloride		/	Unkown
HY-RS00057	ABCC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16913	Abcc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23355	Abcc1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Abcc1	NCBI	NCBI:4363

Name
Email *

	Sorry, but the email address you supplied was invalid.