Ascl2 - achaete-scute family bHLH transcription factor 2 Gene

Mus musculus

Also known as Mash2; bHLHa45; 2410083I15Rik

Gene ID: 17173 | Gene type: protein coding

About Ascl2

Summary

Enables sequence-specific DNA binding activity. Acts upstream of or within regulation of transcription by RNA polymerase II; somatic stem cell population maintenance; and spongiotrophoblast differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and musculoskeletal system. Orthologous to human ASCL2 (achaete-scute family bHLH transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ascl2 Products(1)

mRNA	Protein	Name
NM_008554.3	NP_032580.2	achaete-scute homolog 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10611232	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IGI IGI: Inferred from genetic interaction	10611232	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	24463518	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IGI IGI: Inferred from genetic interaction	10611232	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	24463518	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IGI IGI: Inferred from genetic interaction	25620640	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	25620640	MGI
enables bHLH transcription factor binding	IPI IPI: Inferred from physical interaction	10611232	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9676199	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within T cell differentiation	IMP IMP: Inferred from mutant phenotype	31539517	MGI
involved in T follicular helper cell differentiation	IMP IMP: Inferred from mutant phenotype	24463518	MGI
acts upstream of or within cell differentiation	IMP IMP: Inferred from mutant phenotype	8090202	MGI
involved in chorionic trophoblast cell development	IMP IMP: Inferred from mutant phenotype	7773285	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	8090202	MGI
involved in negative regulation of T-helper 1 cell differentiation	IMP IMP: Inferred from mutant phenotype	24463518	MGI
involved in negative regulation of T-helper 17 cell differentiation	IMP IMP: Inferred from mutant phenotype	24463518	MGI
involved in negative regulation of T-helper 2 cell differentiation	IMP IMP: Inferred from mutant phenotype	24463518	MGI
involved in negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	10611232	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24463518	MGI
acts upstream of or within placenta development	IMP IMP: Inferred from mutant phenotype	21238448	MGI
involved in positive regulation of T cell migration	IMP IMP: Inferred from mutant phenotype	24463518	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10611232	MGI
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	10611232	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	24463518	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19796622	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	9676199	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	19269367	MGI
acts upstream of or within spongiotrophoblast differentiation	IMP IMP: Inferred from mutant phenotype	9331331	MGI
involved in stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	25620640	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23372768	MGI
located in nucleus	IDA IDA: Inferred from direct assay	19269367	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

achaete-scute homolog 2

ASH-2	achaete-scute complex homolog 2
achaete-scute complex homolog-like 2	long transient receptor potential-related channel 5
mASH-2	mammalian achaete scute homolog 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01079	ASCL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20860	Ascl2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27375	Ascl2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ascl2	NCBI	NCBI:430

Name
Email *

	Sorry, but the email address you supplied was invalid.