Lef1 - lymphoid enhancer binding factor 1 Gene

Mus musculus

Also known as Lef-1; 3000002B05

Gene ID: 16842 | Gene type: protein coding

About Lef1

Summary

Enables DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and chromatin binding activity. Involved in several processes, including T-helper 1 cell differentiation; positive regulation of gamma-delta T cell differentiation; and secondary palate development. Acts upstream of or within several processes, including animal organ development; blood vessel morphogenesis; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of beta-catenin-TCF complex. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in ovarian Cancer. Orthologous to human LEF1 (lymphoid enhancer binding factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Lef1 Products(7)

mRNA	Protein	Name
NM_001276402.2	NP_001263331.1	lymphoid enhancer-binding factor 1 isoform b
NM_001276403.1	NP_001263332.1	lymphoid enhancer-binding factor 1 isoform c
NM_001379059.1	NP_001365988.1	lymphoid enhancer-binding factor 1 isoform d
NM_001379060.1	NP_001365989.1	lymphoid enhancer-binding factor 1 isoform e
NM_001379061.1	NP_001365990.1	lymphoid enhancer-binding factor 1 isoform f
NM_001379062.1	NP_001365991.1	lymphoid enhancer-binding factor 1 isoform g
NM_010703.5	NP_034833.2	lymphoid enhancer-binding factor 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	7774816	MGI
enables DNA binding, bending	EXP EXP: Inferred from Experiment	15236581	MGI
enables DNA binding, bending	IDA IDA: Inferred from direct assay	7774816	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12244173	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11696550	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IGI IGI: Inferred from genetic interaction	15729346	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	30659184	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12244173	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	15024079	MGI
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15545629	MGI
enables nucleic acid binding	EXP EXP: Inferred from Experiment	15236581	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11696550	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21750544	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	7537238	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	12551949	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell proliferation	IMP IMP: Inferred from mutant phenotype	10933391	MGI
acts upstream of or within BMP signaling pathway	IDA IDA: Inferred from direct assay	9769173	MGI
acts upstream of or within T cell receptor V(D)J recombination	IGI IGI: Inferred from genetic interaction	9462507	MGI
involved in T-helper 1 cell differentiation	IDA IDA: Inferred from direct assay	18579517	MGI
acts upstream of or within alpha-beta T cell differentiation	IGI IGI: Inferred from genetic interaction	9462507	MGI
acts upstream of or within anatomical structure regression	IMP IMP: Inferred from mutant phenotype	16163358	MGI
acts upstream of or within apoptotic process involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	16163358	MGI
acts upstream of or within apoptotic process involved in morphogenesis	IMP IMP: Inferred from mutant phenotype	15649466	MGI
acts upstream of or within branching involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	19154719	MGI
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	9769173	MGI
involved in canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	10933391	MGI
involved in canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	16678815	MGI
acts upstream of or within cell development	IGI IGI: Inferred from genetic interaction	15729346	MGI
acts upstream of or within chorio-allantoic fusion	IGI IGI: Inferred from genetic interaction	10090727	MGI
acts upstream of or within dentate gyrus development	IMP IMP: Inferred from mutant phenotype	10631168	MGI
acts upstream of or within embryonic limb morphogenesis	IGI IGI: Inferred from genetic interaction	10090727	MGI
acts upstream of or within epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	15649466	MGI
involved in epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	14691138	MGI
acts upstream of or within face morphogenesis	IGI IGI: Inferred from genetic interaction	17699607	MGI
acts upstream of or within forebrain neuroblast division	IGI IGI: Inferred from genetic interaction	14715945	MGI
acts upstream of or within forebrain radial glial cell differentiation	IGI IGI: Inferred from genetic interaction	14715945	MGI
acts upstream of or within formation of radial glial scaffolds	IGI IGI: Inferred from genetic interaction	14715945	MGI
acts upstream of or within hippocampus development	IMP IMP: Inferred from mutant phenotype	10631168	MGI
acts upstream of or within mammary gland development	IMP IMP: Inferred from mutant phenotype	16678815	MGI
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12551949	MGI
acts upstream of or within negative regulation of striated muscle tissue development	IDA IDA: Inferred from direct assay	16936075	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16678101	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IGI IGI: Inferred from genetic interaction	17699607	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IMP IMP: Inferred from mutant phenotype	12502739	MGI
acts upstream of or within paraxial mesoderm formation	IGI IGI: Inferred from genetic interaction	10090727	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10631168	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	10933391	MGI
acts upstream of or within positive regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	30659184	MGI
acts upstream of or within positive regulation of chondrocyte proliferation	IMP IMP: Inferred from mutant phenotype	30659184	MGI
involved in positive regulation of gamma-delta T cell differentiation	IMP IMP: Inferred from mutant phenotype	23562159	MGI
involved in positive regulation of odontoblast differentiation	IMP IMP: Inferred from mutant phenotype	29148101	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12475749	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12244173	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15094381	MGI
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	20371816	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17284610	MGI
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	23562159	MGI
acts upstream of or within regulation of Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	10090727	MGI
acts upstream of or within regulation of cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	19154719	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11696550	MGI
involved in secondary palate development	IMP IMP: Inferred from mutant phenotype	14691138	MGI
acts upstream of or within sensory perception of taste	IMP IMP: Inferred from mutant phenotype	17284610	MGI
acts upstream of or within somitogenesis	IGI IGI: Inferred from genetic interaction	10090727	MGI
acts upstream of or within somitogenesis	IMP IMP: Inferred from mutant phenotype	15545629	MGI
acts upstream of or within sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	19154719	MGI
acts upstream of or within tongue development	IMP IMP: Inferred from mutant phenotype	17284610	MGI
acts upstream of or within trachea gland development	IMP IMP: Inferred from mutant phenotype	10498680	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17284610	MGI
acts upstream of or within vasculature development	IMP IMP: Inferred from mutant phenotype	16163358	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	21075118	MGI
part of beta-catenin-TCF complex	IDA IDA: Inferred from direct assay	20371816	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	14623238	MGI
located in nucleus	IDA IDA: Inferred from direct assay	7537238	MGI
is active in nucleus	IPI IPI: Inferred from physical interaction	30659184	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	30659184	MGI
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	11696550	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

lymphoid enhancer-binding factor 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07584	LEF1 Human Pre-designed siRNA Set A	Pre-designed Sets	≥90.0%	Unkown
HY-RS18620	Lef1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25106	Lef1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lef1	NCBI	NCBI:51176

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